NEUTROPHILS CONTRIBUTE TO VASCULITIS BY INCREASED RELEASE OF NEUTROPHIL EXTRACELLULAR TRAPS IN BEHÇET’S DISEASE

Bechet's disease (BD) is an inflammatory multi-system disorder causing recurrent oral and genital ulcers, uveitis, and vasculitis, in addition to cutaneous, neurological, gastrointestinal, articular and pulmonary manifestations [1]. Mild cases are treated with Colchicine, an anti-inflammatory drug. Severe cases can be life threatening and require systemic steroids, anti-TNFα drugs and immunosuppressants. Its pathophysiology is poorly known. Genetic studies identified several susceptibility loci implicating MHC1 and innate immunity genes namely HLA-B51, ERAP1, IL10, IL23R-IL12RB2, and IL1 A-IL1B [2–4].