Hyperglycosylated spike of SARS-CoV-2 gamma variant induces breast cancer metastasis

xlomafota13 shared this article with you from Inoreader Hyperglycosylated spike of SARS-CoV-2 gamma variant induces breast cancer metastasis Via American Journal of Cancer Research Am J Cancer Res. 2021 Oct 15;11(10):4994-5005. eCollection 2021. ABSTRACT SARS-CoV-2 exploits the host cellular machinery for virus replication leading to the acute syndrome of coronavirus disease 2019 (COVID-19). Growing evidence suggests SARS-CoV-2 also exacerbates many chronic diseases, including cancers. As mutations on the spike protein (S) emerged as dominant variants that reduce vaccine efficacy, little is known about the relation between SARS-CoV-2 virus variants and cancers. Compared to the SARS-CoV-2 wild-type, the Gamma variant contains two additional NXT/S glycosylation motifs on the S protein. The hyperglycosylated S of Gamma variant is more stable, resulting in more significant epithelial-mesenchymal transition (EMT) potential. SARS-CoV-2 infection promoted NF-κB signaling activation and p65 nuclear translocation, inducing Snail expression. Pharmacologic inhibition of NF-κB activity by nature food compound, I3C suppress ed viral replication and Gamma variant-mediated breast cancer metastasis, indicating that NF-κB inhibition can reduce chronic disease in COVID-19 patients. Our study revealed that the Gamma variant of SARS-CoV-2 activates NF-κB and, in turn, triggers the pro-survival function for cancer progression. PMID:34765306 | PMC:PMC8569360 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.