Boron-containing nucleosides as tools for boron-neutron capture therapy

xlomafota13 shared this article with you from Inoreader Boron-containing nucleosides as tools for boron-neutron capture therapy Via American Journal of Cancer Research Am J Cancer Res. 2021 Oct 15;11(10):4668-4682. eCollection 2021. ABSTRACT Despite the significant progress in cancer cure, the development of new approaches to cancer therapy is still of great importance since many deadly tumors remain untreatable. Boron neutron capture therapy (BNCT), proposed more than eighty years ago, is still considered a potentially advantageous approach. Irradiation of cells containing 10B isotopes with epithermal neutrons and the consequent decay of boron nuclei releases particles that deposit high energy along a very short path, inflicting heavy damage on the target cells but sparing the neighbouring tissue. Delivery and preferential accumulation of boron in cancer cells are the major obstacles that slow down the clinical use of BNCT. Since DNA damage caused by irradiation is the major reason for cell death, the incorporation of boron-containing nucleotides into the DNA of cancer cells may significa ntly increase the efficacy of BNCT. In this review, we discuss the current state of knowledge in the synthesis of boron-containing nucleosides and their application for BNCT with a special focus on their possible incorporation into genomic DNA. PMID:34765286 | PMC:PMC8569357 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.