Relationship Between Radiation Pneumonitis Following Definitive Radiotherapy for Non-small Cell Lung Cancer and Isodose Line

xlomafota13 shared this article with you from Inoreader Relationship Between Radiation Pneumonitis Following Definitive Radiotherapy for Non-small Cell Lung Cancer and Isodose Line Via In vivo (Athens, Greece) In Vivo. 2021 Nov-Dec;35(6):3441-3448. doi: 10.21873/invivo.12644. ABSTRACT BACKGROUND/AIM: It is important to identify radiation pneumonitis above Common Terminology Criteria for Adverse Events Grade 2 (G2) in order to safely continue durvalumab maintenance after chemoradiotherapy for advanced lung cancer. The aim of this study was to discover factors that predict pneumonitis above G2. PATIENTS AND METHODS: A follow-up computed tomography (CT) image was superimposed on the planning CT image using deformable image registration (DIR). The pneumonitis area was contoured on follow-up CT after DIR and the dose-volume histogram parameters of the contoured pneumonitis area were calculated. RESULTS: V5 (Percentage of total volume receiving ≥5 Gy) to V50 of pneumonitis were significantly lower in patients with G2 pneumonitis than in those with G1 pneumonitis. The pneumonitis V15 was the most significant. The group with pneumoniti s V15 <87.10% had significantly more G2 pneumonitis than the group with pneumonitis V15 ≥87.10%. CONCLUSION: Pneumonitis V15 <87.10% was a risk factor for G2 pneumonitis. PMID:34697180 | DOI:10.21873/invivo.12644 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.