Protection and safety of a repeated dosage of KI for iodine thyroid blocking during pregnancy

xlomafota13 shared this article with you from Inoreader Protection and safety of a repeated dosage of KI for iodine thyroid blocking during pregnancy Via radioactive iodine J Radiol Prot. 2021 Oct 26. doi: 10.1088/1361-6498/ac336e. Online ahead of print. ABSTRACT In case of nuclear power plant accidents resulting in the release of radioactive iodine (131I) in large amounts, a single intake of stable iodine is recommended in order to prevent 131I fixation to the thyroid gland. However, in situations of prolonged exposure to 131I (e.g. Fukushima-Daiichi natural and nuclear disaster), repetitive administration of iodine may be necessary to ensure adequat e protection, with acceptable safety in vulnerable populations including pregnant women. Here we conducted toxicological studies on adult rats progeny following prolonged exposure to potassium iodide (KI) in utero. Pregnant Wistar rats were treated with 1mg/kg/day KI or saline water for 2 or 4 days either between gestation days GD 9 -12, or GD13-16. Plasma samples from the progeny were tested 30 days post-weaning for clinical biochemistry, thyroid hormones, and anti-thyroid antibody levels. Thyroid and brain were collected for gene expression analysis. The hormonal status was similar for the mothers in all experimental conditions. In the offspring, while TSH and anti-TPO antibody levels were similar in all groups, a significant increase of FT3 and FT4 levels was observed in GD9-GD10 and in GD13-GD14 animals treated for 2 days, respectively. In addition, FT4 levels were mildly decreased in 4-day treated GD13-16 individuals. Moreover, a significant decrease in the expression level of thyroid genes involved in iodide metabolism, TPO and AIT, was observed in GD13-GD14 animals treated for 2 days. We conclude that repeated KI administration for 2-4 days during gestation did not induce strong thyroid toxicity. PMID:34700314 | DOI:10.1088/1361-6498/ac336e View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.