Role of FoxO1 in regulating autophagy in type 2 diabetes mellitus (Review)

xlomafota13 shared this article with you from Inoreader Role of FoxO1 in regulating autophagy in type 2 diabetes mellitus (Review) Via Experimental and therapeutic medicine Exp Ther Med. 2021 Jul;22(1):707. doi: 10.3892/etm.2021.10139. Epub 2021 May 2. ABSTRACT Type 2 diabetes mellitus (T2DM) is a major chronic disease that is characterized by pancreatic β-cell dysfunction and insulin resistance. Autophagy is a highly conserved intracellular recycling pathway and is involved in regulating intracellular homeostasis. Transcription factor Forkhead box O1 (FoxO1) also regulates fundamental cellular processes, including cell differentiation, metabolism and apoptosis, and proliferation to cellular stress. Increasing evidence suggest that autophagy and FoxO1 are involved in the pathogenesis of T2DM, including β-cell viability, apoptosis, insulin secretion and peripheral insulin resistance. Recent studies have demonstrated that FoxO1 improves insulin resistance by regulating target tissue autophagy. The present review summarizes current literature on the role of autophagy and FoxO1 in T2DM. The participation of FoxO1 in the development and occurrence of T2DM via autophagy is also discussed. PMID:34007316 | PMC:PMC8120662 | DOI:10.3892/etm.2021.10139 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.