Histone demethylase KDM2A: Biological functions and clinical values (Review)

xlomafota13 shared this article with you from Inoreader Histone demethylase KDM2A: Biological functions and clinical values (Review) Via Experimental and therapeutic medicine Exp Ther Med. 2021 Jul;22(1):723. doi: 10.3892/etm.2021.10155. Epub 2021 May 4. ABSTRACT Histone lysine demethylation modification is a critical epigenetic modification. Lysine demethylase 2A (KDM2A), a Jumonji C domain-containing demethylase, demethylates the dimethylated H3 lysine 36 (H3K36) residue and exerts little or no activity on monomethylated and trimethylated H3K36 residues. KDM2A expression is regulated by several factors, such as microRNAs, and the phosphorylation of KDM2A also plays a vital role in its function. KDM2A mainly recognizes the unmethylated region of CpG islands and subsequently demethylates histone H3K36 residues. In addition, KDM2A recognizes and binds to phosphorylated proteins, and promotes their ubiquitination and degradation. KDM2A plays an important role in chromosome remodeling and gene transcription, and is involved in cell proliferation and differentiation, cell metabolism, heterochromosomal homeostas is and gene stability. Notably, KDM2A is crucial for tumorigenesis and progression. In the present review, the documented biological functions of KDM2A in physiological and pathological processes are comprehensively summarized. PMID:34007332 | PMC:PMC8120640 | DOI:10.3892/etm.2021.10155 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.