Predictive factors of radioiodine therapy failure in Graves' Disease: A meta-analysis

xlomafota13 shared this article with you from Inoreader Predictive factors of radioiodine therapy failure in Graves' Disease: A meta-analysis Via radioactive iodine Am J Surg. 2021 Apr 14:S0002-9610(21)00229-4. doi: 10.1016/j.amjsurg.2021.03.068. Online ahead of print. ABSTRACT BACKGROUND: I-131 therapy is a common treatment modality for adults with Graves' Disease (GD). Utilizing meta-analysis, we examined patient specific factors that predict I-131 therapy failure. METHODS: Literature search followed PRISMA. Comprehensive Meta-analysis (version 3.0) was used. Mantel-Haenszel test with accompanying risk ratio and confidence intervals ev aluated categorical variables. Continuous data was analyzed using inverse variance testing yielding mean difference or standardized mean difference. Decision tree algorithms identified variables of high discriminative performance. RESULTS: 4822 collective patients across 18 studies were included. Male sex (RR = 1.23, 95%CI = 1.08-1.41, p = 0.002), I-131 therapy 6 months after GD diagnosis (RR = 2.10, 95%CI = 1.45-3.04, p < 0.001) and history of anti-thyroid drugs (RR = 2.05, 95%CI = 1.49-2.81, p < 0.001) increased the risk of I-131 therapy failure. Elevated free thyroxine, 24-h radioactive iodine uptake scan ≥60.26% and thyroid volume ≥35.77 mL were also associated with failure. CONCLUSION: Patient characteristics can predict the likelihood of I-131 therapy failure in GD. Definitive surgical treatment may be a reasonable option for those patients. PMID:33865565 | DOI:10.1016/j.amjsurg.2021.03.068 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.