Braz J Otorhinolaryngol. 2021 Apr 3:S1808-8694(21)00062-8. doi: 10.1016/j.bjorl.2021.03.003. Online ahead of print.
ABSTRACT
INTRODUCTION: Severe uncontrolled chronic rhinosinusitis with nasal polyps has a negative impact on an individual's quality of life. Therefore, new biologics have emerged for use in specific phenotypes of chronic rhinosinusitis, changing the paradigms of its treatment.
OBJECTIVE: To review the current status of biologic treatment indications in chronic rhinosinusitis.
METHODS: The Brazilian Academy of Rhinology brought together different specialists to suggest a course of action, considering its particularities and aspects related to the national reality.
RESULTS: Of particular interest for decision making will be the identification of subgroups of patients refractory to pre-existing treatment options and the construction of a strategy that improves their quality of life, with the best cost-bene fit ratio.
CONCLUSION: The use of biologics is a valid option for treatment in more severe cases. This strategy must be better understood and improved in the future, with more studies and greater clinical experience.
PMID:33867274 | DOI:10.1016/j.bjorl.2021.03.003
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