RNA‐protein interactions: Central players in coordination of regulatory networks

payt.helady61 shared this article with you from Inoreader RNA‐protein interactions: Central players in coordination of regulatory networks Via BioEssays The crosstalk among protein, RNA and DNA interaction networks guarantees cellular homeostasis. Here we discuss the emerging concept that nucleic acids and especially RNA molecules can act as 'solubilizers' to promote liquid‐like phase separation. Disruption of interactions with RNA and DNA increase the propensity to undergo pathological liquid‐to‐solid phase transitions. Abstract Changes in the abundance of protein and RNA molecules can impair the formation of complexes in the cell leading to toxicity and death. Here we exploit the information contained in protein, RNA and DNA interaction networks to provide a comprehensive view of the regulation layers controlling the concentration‐dependent formation of assemblies in the cell. We present the emerging concept that RNAs can act as scaffolds to promote the formation ribonucleoprotein complexes and coordinate the post‐transcriptional layer of gene regulation. We describe the structural and interaction network properties that characterize the ability of protein and RNA molecules to interact and phase separate in liquid‐like compartments. Finally, we show that presence of structurally disordered regions in proteins correlate with the propensity to undergo liquid‐to‐solid phase transitions and cause human diseases. Also see the video abstract here https://youtu.be/kfpqibsNfS0 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.