Intrinsic disorder in the T cell receptor creates cooperativity and controls ZAP70 binding

payt.helady61 shared this article with you from Inoreader Intrinsic disorder in the T cell receptor creates cooperativity and controls ZAP70 binding Via Biophysical Journal Many immunoreceptors have cytoplasmic domains that are intrinsically disordered (i.e., have high configurational entropy), have multiple sites of post-translational modification (e.g., tyrosine phosphorylation), and participate in nonlinear signaling pathways (e.g., exhibiting switch-like behavior). Several hypotheses to explain the origin of these nonlinearities fall under the broad hypothesis that modification at one site changes the immunoreceptor's entropy, which in turn changes further modification dynamics. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.