Immunoexpression of BDNF, TrkB and p75NTR receptors in peripheral neural lesions of the head and neck

xloma.fota13 shared this article with you from Inoreader Immunoexpression of BDNF, TrkB and p75NTR receptors in peripheral neural lesions of the head and neck Via Oral Pathology & Medicine Abstract Background Brain‐derived neurotrophic factor (BDNF) and neurotrophin receptors have been recognized as fundamental regulators of normal brain development, homeostasis and plasticity. They have also been studied in the behavior of central nervous system tumors. Here we studied the pattern of BDNF, TrkB and p75NTR immunoexpression in peripheral benign and malignant neural lesions in head and neck. Methods This cross‐sectional analytical study included 79 cases of head and neck neural lesions. Nineteen cases of traumatic neuromas (TN), 20 cases of granular cell tumors (GCT), 16 cases of neurofibromas (NF), 20 cases of schwannomas (SC) and 4 malignant peripheral nerve sheath tumour (MPNST) were submitted to immunohistochemistry with BDNF, TrkB and p75NTR antibodies. A semi‐quantitative analysis was performed. Results The analysis of BDNF demonstrated a high percentage of positive cells in TN, GCT and SC with a decrease in cases of NF and MPNST. TrkB presented a lower significant immunoexpression in GCT in relation to the TN, NF, SC and MPNST (p < 0.0001); and TN showed less percentage of positive cell compared to SC (p = 0.0017). Regarding p75NTR, the percentage of positive cell was significantly reduced in MPNST compared GCT (p = 0.009), NF (p = 0.0138) and SC (p = 0.0069). Also, a decrease in TN compared to GCT (p = 0.007) were observed. Conclusions Our results showed the immunoreactivity of BDNF, TrkB and p75NTR in head and neck peripheral neural lesions. Reduction of BDNF and p75NTR in MPNST might suggest downregulation during the acquisition of malignant phenotype. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.