Case and Review: Cutaneous Involvement by Chronic Neutrophilic Leukemia versus Sweet Syndrome, a Diagnostic Dilemma

xloma.fota13 shared this article with you from Inoreader Case and Review: Cutaneous Involvement by Chronic Neutrophilic Leukemia versus Sweet Syndrome, a Diagnostic Dilemma Via Journal of Cutaneous Pathology Abstract Chronic neutrophilic leukemia (CNL) is a rare leukemia with approximately 150 total cases reported. Cutaneous neutrophilic infiltrates, including Sweet syndrome (SS) and leukemia cutis (LC), have been reported in six patients with CNL. In the setting of CNL, these two conditions are difficult to differentiate due to clinical and histological similarities, but it is important to do so because leukemia cutis is associated with a worse prognosis. In general, Sweet syndrome is distinguished by its tenderness, fever, and improvement with steroids (vs chemotherapy for LC). Biopsy of LC reveals immature leukocytes, whereas SS shows almost exclusively mature leukocytes, but morphology alone may not be sufficient in some cases. Here we report a case of a 72‐year‐old male with CNL and a cutaneous eruption with clinical and pathologic features which made the distinction between the two diseases difficult. This article is protected by copyright. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.