Evaluation of cancer-derived myocardial impairments using a mouse model.

a.sfakia shared this article with you from Inoreader Evaluation of cancer-derived myocardial impairments using a mouse model. Via Oncotarget,Albany, N.Y. : Impact Journals,http://www.impactjournals.com/oncotarget/ Related Articles Evaluation of cancer-derived myocardial impairments using a mouse model. Oncotarget. 2020 Oct 13;11(41):3712-3722 Authors: Miyagawa Y, Nukaga S, Mori T, Fujiwara-Tani R, Fujii K, Mori S, Goto K, Kishi S, Sasaki T, Nakashima C, Ohmori H, Kawahara I, Luo Y, Kuniyasu H Abstract Myocardial damage in cancer patients is emphasized as a cause of death; however, there are not many murine cachexia models to evaluate cancer-derived heart disorder. Using the mouse cachexia model that we established previously, we investigated myocardial damage in tumor-bearing mice. In cachexic mice, decreased heart weight and myocardial volume, and dilated left ventricular lumen, and atrophied cardiomyocytes were noted. The cardiomyocytes also showed accumulated 8-hydroxydeoxyguanosine, decreased leucine zipper and EF-hand-containing transmembrane protein-1, and increased microtubule-associated protein light chain3-II. Levels of tumor necrosis factor-α and high-mobility group box-1 proteins in the myocardium were increased, and nuclear factor κB, a signaling molecule associated with these proteins, was activated. When rat cardiomyoblasts (H9c2 cells) were treated with mouse cachexia model ascites and subjected to flux analysis, both oxidative phosphorylation and glycolys is were suppressed, and the cells were in a quiescent state. These results are in good agreement with those previously reported on cancerous myocardial damage. The established mouse cachexia model can therefore be considered useful for analyzing cancer-derived myocardial damage. PMID: 33110478 [PubMed] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.