A Comprehensive Review on DNA Gyrase Inhibitors.

a.sfakia shared this article with you from Inoreader A Comprehensive Review on DNA Gyrase Inhibitors. Via Infectious disorders drug targets,http://goo.gl/XqkpND Related Articles A Comprehensive Review on DNA Gyrase Inhibitors. Infect Disord Drug Targets. 2020 Jan 01;: Authors: Chitra SR, Ramalakshmi N, Kumar SA, Manimegalai P Abstract The newly emerging infectious organisms, the global crisis in antibiotic resistance, and the threat of bioterrorism create an urgent need to discover novel antimicrobial agents. In order to develop novel antimicrobial agents, the mechanism of infectious disease must be better understood. DNA Gyrase is a bacterial enzyme that plays an important role in the replication of DNA and transcription process. It is not present in higher eukaryotes making it a perfect target for developing new antibacterial agents. This review describes the role of DNA gyrase inhibitors in preventing various diseases. In this review, we outline the synthesis and pharmacological action of various novel DNA gyrase inhibitors. DNA gyrase inhibitors were used to treat tuberculosis, bacterial, fungal infections and malaria. DNA gyrase inhibitors mainly act by preventing the supercoiling of DNA strands. PMID: 33109068 [PubMed - as supplied by publisher] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.