Syringaresinol reverses age-related skin atrophy by suppressing FoxO3a-mediated MMP2 activation in SOD1-deficient mice

Aging is characterized by accumulation of chronic and irreversible oxidative damage, chronic inflammation, and organ dysfunction. Superoxide dismutase (SOD) serves as a major enzyme for cellular superoxide radical metabolism and physiologically regulates cellular redox balance throughout the body. The copper/zinc superoxide dismutase (SOD1)-deficient mice showed diverse phenotypes associated with enhanced oxidative damage in whole organs. Here, we found that oral treatment with syringaresinol (SYR, also known as lirioresinol B), which is the active component in the berries of Korean ginseng (Panax ginseng C.A.Meyer), attenuated the age-related changes in Sod1-/- skin.