Chemoprotective effects of dietary grape powder on ultraviolet B radiation-mediated skin carcinogenesis in SKH-1 hairless mice

Skin cancer is the most frequently diagnosed cancer in the US, and solar ultraviolet (UV) radiation is an established causative factor for ∼90% of these cases. Despite efforts aimed at UV protection, including use of sunscreen and clothing, annual cases of skin cancers continue to rise. Here, we report that dietary grape powder (GP) mitigates UVB-mediated skin carcinogenesis in SKH-1 hairless mouse model. Employing a UVB initiation-promotion protocol, where mice were exposed to 180 mJ/cm2 UVB 2x/week for 28 weeks, we determined the effects of GP-fortified diet (3% or 5%) on skin carcinogenesis.