Granulomatous dermatitis as a postherpetic isotopic response in immunocompromised patients: A report of 5 cases

Granulomatous dermatitis (GD) describes disorders in which mixed inflammatory infiltrates composed primarily of histiocytes invade the skin. The pathogenesis of GD is unknown; however, GD has been noted to occur in areas previously affected by trauma, sun damage, or infection.1 When GD presents at the same site of a healed, unrelated skin disease, it falls within the category of a Wolf's isotopic response.2 The regional restriction of a Wolf's isotopic response is proposed to occur due to an area of localized immunocompromise known as an immunocompromised district.