Acquired epidermodysplasia verruciformis in setting of tumor necrosis factor-α inhibitor therapy

Epidermodysplasia verruciformis (EV) is a rare dermatologic condition in which patients have recalcitrant lesions associated with specific human papillomavirus (HPV) types. More than 20 types of HPV are associated with EV (termed EV-HPV types) and most commonly include HPV 5 and 8.1-3 First described as a genodermatosis, it has more recently been reported as an acquired form in patients with an underlying source of immunosuppression, namely, HIV.2 It has not been reported in patients on tumor necrosis factor (TNF)-α inhibitors.