The effectiveness of adding low-level light therapy to minoxidil 5% solution in the treatment of patients with androgenetic alopecia

Gita Faghihi, Samaneh Mozafarpoor, Ali Asilian, Fatemeh Mokhtari, Alireza Asemi Esfahani, Behzad Bafandeh, Saeid Nouraei, Mohammad Ali Nilforoushzadeh, Seyed Mohsen Hosseini

Indian Journal of Dermatology, Venereology, and Leprology 2018 84(5):547-553

Background: Androgenetic alopecia is the commonest type of alopecia affecting over half of men and women. Low-level light therapy is a new technique for stimulating hair growth in both genders. Aims: To overcome the shortcomings of previous epidemiological studies and a lack of controlled clinical trials on the subject, this study compared the effectiveness of adding low-level light therapy to minoxidil topical solution in the treatment of androgenetic alopecia in patients presenting to two skin clinics in Isfahan, Iran during 2014–2015. Materials and Methods: This clinical trial included 50 patients aged 17–45 presenting to Khorshid and Alzahra educational centers and skin diseases research center for androgenetic alopecia during 2014–2015. The patients were randomly divided into a control and a case group. The case group received topical minoxidil 5% solution plus low-level light therapy twice per day. The control group was given the same topical solution and a laser comb system that was turned off to act as a placebo. Changes in patients' hair density and diameter and its overall regrowth as well as their satisfaction with the treatment were assessed at months 0 (baseline), 3, 6, 9 and 12. Results: The percentage of recovery from androgenetic alopecia and the patients' satisfaction with their treatment were significantly higher in the case group compared to the control group. The patients' mean hair density and diameter were found to be higher in the case group after the intervention compared to the control group. Limitations: The study limitations included patient compliance, small sample size, patient insight due to novelty of the method and clinical judgement. Conclusion: As a new method of treatment, low-level light therapy can help improve the percentage of recovery from androgenetic alopecia and increase patients' satisfaction with their treatment.