Impact of genital lichen sclerosus treatments on occurrence of vulvar neoplasms in 275 adult women

Background: Lichen sclerosus (LS) is a chronic inflammatory disease most commonly affecting the genital area of women. LS-associated vulvar neoplasms are known to occur. Treatment of LS is thought to reduce malignancy risk. A recent report showed reduction in vulvar neoplasms in those compliant with maintenance therapy. We performed a single-institution, retrospective chart review to identify vulvar neoplasm occurrence in women with biopsy-proven genital LS and to determine whether a correlation exists between LS treatments and vulvar neoplasm occurrence.