Erlotinib-induced erosive pustular dermatosis of the scalp complicated by MRSA infection

Introduction: Erosive pustular dermatosis (EPD) of the scalp is a rare entity characterized by erosive, follicular, papulopustular eruptions with nonspecific chronic inflammatory findings on histopathology. EPD of the scalp has been associated with epidermal growth factor receptor (EGFR) inhibitor therapy such as gefitinib or erlotinib with only a few reported cases. Herein, we report an impressive presentation of EPD of the scalp complicated by secondary methicillin-resistant Staphlococcus aureus (MRSA) infection during treatment with erlotinib for stage IV lung cancer.