Systemic lupus erythematosus and antineutrophil cytoplasmic antibody–associated vasculitis: An emerging overlap syndrome with cutaneous manifestations

Systemic lupus erythematosus and antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (SLE/AAV) overlap syndrome is a rare disease originally described in 2008.1 With only a few reports in the literature, this condition is characterized by aggressive crescentic glomerulonephritis, arthritis, cutaneous involvement, and both antinuclear antibody (ANA) and ANCA. Dermatologic manifestations are common and may occur at initial presentation.2 Although skin lesions may vary in morphology, the most commonly reported include cutaneous nodules and ecchymoses.