DNAJA4 Deficiency Enhances NF-kappa B-related Growth Arrest Induced by Hyperthermia in Human Keratinocytes

Exogeneous hyperthermia, defined as a 30–60 minute exposure to a thermal stimulus of 40–44 °C, has been employed in treatment of an array of diseases [1]. This technique has proved effective in the treatment of various of cancers such as cervical, bladder and head and neck cancer [2–4]. Within our clinic we have used local hyperthermia at 44 ± 0.1 °C in the treatment of plantar warts and found this procedure to be more effective than that of conventional therapies [5,6]. With this method, we have also successfully alleviated cutaneous warts in patients with diabetes mellitus [7], systemic lupus erythematosus (SLE) [8], Darier disease [9] and pregnancy [10], all of which had experienced failures with conventional treatments.