95PEnergy restriction as a novel approach targeting breast cancer stem cells multi-drug resistance

Background: Breast cancer (BC) is the most commonly diagnosed cancer in women worldwide. The progression, metastasis and drug resistance of breast cancer cells were suggested to be driven by a special population within the tumor called cancer stem cells (CSC). Targeting CSC is extremely challenging due to the high expression levels of ATP-binding cassette (ABC) transporters which facilitates the multi drug resistance (MDR) capacity of CSC. The aim of this work was to test whether Energy restriction mimetic agents (ERMAs) as OSU-CG5 can counteract cancer multidrug resistance by limiting the availability of energy in CSC. In addition to exploit the mechanistic synergy between OSU-CG5 and a conventional chemotherapeutic agent as Doxorubicin.