109PMultiphysics modelling of alpha-immuno-conjugate delivery and background dose

Background: Radiotherapy is one of the commonly used approaches to treat cancer. The research trend and breakthroughs in radiotherapy is focusing on the high linear energy transfer (LET) radiation like the alpha particles. Thus, the alpha particles based method is an important option of radiotherapy development, and Targeted Alpha Therapy (TAT) is the most important application of using alpha particles in the past decade. This paper highlights the research work done on computational modelling of TAT at Canadian Nuclear Laboratories (CNL).