Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: Case report of severe multiorgan involvement to perindopril/amlodipine combination antihypertensive

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a life-threatening adverse drug reaction with an up to 10% mortality rate. It is characterized by fever, skin eruption, lymphadenopathy, and systemic organ dysfunction. Aromatic anticonvulsants were the first identified culprit medications.1-3 This condition has a prolonged latency period with clinical disease developing up to 2 months after exposure.1,4-6 We report a case of severe DRESS syndrome secondary to a combination of the antihypertensive medications, perindopril and amlodipine.