Extracellular Matrix Containing in vitro Three-dimensional Tumour Models in Photodynamic Therapy-related Research

Abstract

Three-dimensional (3D) tumour models have been intensively evaluated for their use in cancer research and there is a strong rationale behind using 3D cell cultures in photodynamic therapy (PDT)-related experimentation. In this contribution, it is explained why 3D cell cultures containing extracellular matrix (ECM) are preferred for this purpose. Results of experimental studies utilizing ECM-containing 3D cellular models in PDT research are summarized. Finally, design of in vitro 3D models that would provide clinically relevant information is discussed.

This article is protected by copyright. All rights reserved.