Journal of Cosmetic Dermatology, EarlyView.
Πέμπτη 20 Σεπτεμβρίου 2018
Seasonal aggravation of acne in summers and the effect of temperature and humidity in a study in a tropical setting
Angioedema is an unfavorable factor for the response to omalizumab in chronic spontaneous urticaria: a retrospective study
Dermatologic Therapy, Volume 0, Issue ja, -Not available-.
Recurrent merkel cell carcinoma of the gluteal region: a case report
Dermatologic Therapy, Volume 0, Issue ja, -Not available-.
Atopic‐like dermatitis after Secukinumab injection: a case report
Dermatologic Therapy, Volume 0, Issue ja, -Not available-.
A preliminary study of fractional CO2 laser added to topical tacrolimus combined with 308 nm excimer lamp for refractory vitiligo
Dermatologic Therapy, Volume 0, Issue ja, -Not available-.
New therapeutic vision of Nutrition in dermatology: Integrative Nutrition
Dermatologic Therapy, Volume 0, Issue ja, -Not available-.
Implications of irradiance exposure and non-photochemical quenching for multi-wavelength (bbe FluoroProbe) fluorometry
Publication date: Available online 20 September 2018
Source: Journal of Photochemistry and Photobiology B: Biology
Author(s): Joel W. Harrison, Laura Beecraft, Ralph E.H. Smith
Abstract
Multi-wavelength fluorometers, such as the bbe FluoroProbe (FP), measure excitation spectra of chlorophyll a (Chl-a) fluorescence to infer the abundance and composition of phytoplankton communities as well as the concentration of chromophoric dissolved organic matter (CDOM). Experiments were conducted on laboratory cultures and on natural communities of freshwater phytoplankton to determine how the response of phytoplankton to high irradiance might affect fluorometric estimates of community composition and concentrations of Chl-a and CDOM. Cultures of a representative cyanobacterium, bacillariophyte, synurophyte, cryptophyte, and chlorophyte revealed changes in Chl-a excitation spectra as irradiance was increased to saturating levels and non-photochemical quenching (NPQ) increased. The degree of change and resulting classification error varied among taxa, being strong for the synurophyte and cryptophyte but minimal for the cyanobacterium. Acute-exposure experiments on phytoplankton communities of varying taxonomic composition from five lakes yielded variable results on apparent community composition. There was a consistent decrease in CDOM estimates, whereas Chl-a estimates were generally increased. Subsequent exposure to low PAR relaxed NPQ and tended to reverse the effects of high irradiance on composition, total Chl-a, and CDOM estimates. Relaxation experiments on near-surface communities in a sixth, large lake, Georgian Bay, showed that total Chl-a estimates increased by 44% on average when dark treatments were used to relax NPQ, though, in contrast to the findings from the small lakes, there was little effect on CDOM estimates. We observed a statistically-significant, negative linear relationship between the photon flux density of in situ irradiance and the accuracy of taxonomic assignment by FP in Georgian Bay. Not discounting the correlations between light intensity and the accuracy of the FP that were observed in this study, we conclude that the applicability of the reference spectra to the system under investigation is a more important consideration than variability in natural irradiance conditions.
Effect of laser irradiation on aphthae pain management: A four different wavelengths comparison
Publication date: Available online 20 September 2018
Source: Journal of Photochemistry and Photobiology B: Biology
Author(s): Rocca Jean-Paul, Zhao Meng, Fornaini Carlo, Tan Lixin, Zhao Zengyi, Merigo Elisabetta
Abstract
Recurrent Aphthous Stomatitis (RAS) is an oral condition characterized by painful ulcerations of the mucosa, healing spontaneously in 10–14 days but sometimes, due to their number, size and frequency of recurrence, lesions may be the cause of a severe disconfort with an impact on the quality of life of the patients due to the increased difficulty to eat, swallow and speak.
For RAS, different protocols and treatments have been proposed as standard topical treatment to provide symptomatic relief, immunomodulating drugs as thalidomide, colchicine and steroids have been also proposed with the outcome to relief the pain, accelerating the healing process and increase the duration of ulcer-free period but without definitive results and without side effects.
In this study we analysed the effect of laser treatment of aphthous lesions with four devices available on the market, two with wavelength in the infra-red region (2940 nm 808 nm) and two with a wavelength in the visible region (450 nm and 635 nm).
Diode lasers 808 nm and 450 nm defined almost the same results with an improvement starting already after the application and gradually improving until 7 days after treatment without any statistically significant difference between them. Diode 635 nm was the device gaining the earliest effect reducing the pain already during the treatment and maintaining it at low level immediately after the laser application and after 3 and 7 days with levels of pain comparable with them obtained with 808 nm and 450 nm lasers. Er:YAG laser with the used parameters obtained a pain relief only during the treatment.
The originality of this study was to compare different laser wavelengths, some of them never used for this purpose, and to compare also the two different ways to use lasers, the photobiomodulation (LLLT) and the high-power irradiation.
Mechanism of the photo-induced activation of CoC bond in methylcobalamin-dependent methionine synthase
Publication date: Available online 20 September 2018
Source: Journal of Photochemistry and Photobiology B: Biology
Author(s): Arghya Pratim Ghosh, Abdullah Al Mamun, Piotr Lodowski, Maria Jaworska, Pawel M. Kozlowski
Abstract
Methylcobalamin (MeCbl)-dependent enzyme methionine synthase (MetH), plays a critical role in the catalysis of methyl group transfer from methyltetrahydrofolate (CH3-H4folate) to homocysteine. It often performs a side reaction to generate cob(II)alamin through photolysis of the organometallic CoC bond. A hybrid QM/MM method has been applied to explore the photochemistry of MeCbl-bound MetH. The photolytic properties of MeCbl inside MetH are mediated by its manifold of low-lying excited states. The corresponding potential energy surfaces (PESs) of the electronically excited S1 state has been constructed as a function of axial bond lengths to elucidate the mechanism of photo-induced activation of Co
C bond inside the enzyme. The analysis of the S1 PES has revealed that the two different electronic states of the S1 PES, namely metal-to-ligand charge transfer (MLCT) and the ligand field (LF), are relevant to the photodissociation of the Co
C bond. There are two possible pathways identified, Path A and Path B, that connect the MLCT to LF state that represent possible photodissociation mechanisms. In the case of MetH, one possible photodissociation pathway (Path B) was identified based on the energetics of the MLCT and LF states. The energetically accessible Path B involves the initial detachment of the Co-NIm bond followed by a subsequent displacement of the Co
C bond prior to the formation of cob(II)alamin / CH3 radical pair (RP). The photochemical data of base-on MeCbl in solution was compared with the computed result of MeCbl-bound MetH to understand the effect of the enzymatic environment on the photolytic properties of MeCbl.
Graphical Abstract
Biogenesis of copper oxide nanoparticles (CuONPs) using Sida acuta and their incorporation over cotton fabrics to prevent the pathogenicity of Gram negative and Gram positive bacteria
Publication date: Available online 19 September 2018
Source: Journal of Photochemistry and Photobiology B: Biology
Author(s): Selvam Sathiyavimal, Seerangaraj Vasantharaj, Devaraj Bharathi, Saravanan Mythili, Elayaperumal Manikandan, Smita S. Kumar, Arivalagan Pugazhendhi
Abstract
Textile industry is a major sector providing global financial and employment support to different countries of the world. The major problems of the textile industry are dirt and microbial contaminants affecting the quality of cotton fabrics. Recently, nanoparticles such as silver, chitosan, silicon dioxide, titanium dioxide and zinc oxide have gained attraction in textile industries to avoid the contamination of fabrics through microbes. The necessity to develop an ecofriendly, efficient and cost effective method for the synthesis of nanoparticles is under the radar. Plant extracts serve as potential reducing and coating agents due to the presence of bioactive molecules such as phenols, lipids, carbohydrates, enzymes, protein molecules etc., which endow effective antimicrobial activity to the nanoparticles. In the present study, biological synthesis of Copper oxide nanoparticles (CuONPs) was performed using S. acuta leaf extract. CuONPs were synthesized and characterized using UV–vis, FTIR, SEM and TEM analyses. The antimicrobial property of CuONPs was tested against Gram negative (Escherichia coli and Proteus vulgaris) and Gram positive (Staphylococcus aureus) pathogens, which showed zones of inhibition at different concentrations. As the final part of the study, CuONPs were coated over cotton fabrics showing longer stability, which prevented the growth of infectious pathogens. Apart from the antimicrobial activity, CuONPs synthesized using S. acuta possessed effective photocatalytic activity against commercial dyes.
Graphical Abstract
Whole-Body Vibration and Trunk Posture During Operation of Agricultural Machinery
Abstract
Exposure to whole-body vibration (WBV) is common among agricultural workers and is associated with musculoskeletal health outcomes such as low back pain. Little is known, however, about the characteristics of exposure experienced during actual production practices. We measured WBV levels during agricultural machinery use among a sample of farmers (n = 55) performing routine agricultural activities and explored machinery attributes that may explain WBV summary measures. We also measured trunk posture to provide additional information about physical exposures during machinery operation. Measurements were made on-farm and during actual work conditions of a sample of agricultural machines (n = 112), including tractors, combines, heavy utility vehicles, and all-terrain vehicles (ATVs). Results indicated the presence of high levels of vibration (median frequency-weighted root-mean-square acceleration of approximately 0.8 m s−2) with time signatures that include high-amplitude mechanical shocks (median crest factor of nearly 23). Compared to other machinery types, combines exhibited the lowest WBV levels and among the most favorable trunk postures. Substantial variability was observed in both the WBV and trunk posture summary measures, suggesting for future studies that alternative sampling strategies are needed to fully capture temporal patterns of machinery use.Evaluation of Dermal Exposure to the Herbicide Alachlor Among Vegetable Farmers in Thailand
Abstract
Vegetable farmers applying the herbicide alachlor may be highly exposed through dermal contact when spraying. Dermal patches were attached to 10 locations on the farmers' skin when they mixed and applied alachlor in vegetable farming areas in Thailand. Measurements were made on farmers using either a backpack sprayer with a 2 stroke gasoline motor and fan or a battery operated pump. Forty-seven vegetable farmers in Bungphra subdistrict of Thailand participated in this study. Both motorized and battery pump backpack sprayers wearing long-sleeve shirts had significantly lower alachlor concentrations on the dermal patches under their long-sleeve shirts compared to those who wore only short-sleeve shirts, regardless of the sprayer type. Moreover, sprayers wearing long pants had significantly lower alachlor concentrations on dermal patches placed under the pants on the lower legs than those wearing short pants, regardless of the sprayer type. The highest estimated alachlor exposures were found on the upper legs (median = 9.29 µg/h) for those using a 2 stroke engine/fan backpack sprayer and on the lower legs (2.87 µg/h) for those using the battery operated pump backpack sprayer. The estimated total body alachlor exposures of applicators using the 2 stroke engine/fan backpack sprayer (219.48 µg/h) were significantly higher than those using the battery operated pump backpack sprayer (15.50 µg/h). Using long-sleeve shirts as personal protection reduced alachlor exposures for the arms 97–99% and wearing long pants reduced alachlor exposure to the legs for 81–99%. Thus, training about the protection provided by clothing choices would be one step in improving the health and safety of Thai farmers.Au-delà des kératoses actiniques, le champ de cancérisation cutané
Publication date: Available online 20 September 2018
Source: Annales de Dermatologie et de Vénéréologie
Author(s): P. Reygagne, G. Rostain
Résumé
Les kératoses actiniques (KA) forment des papules érythémateuses, squameuses et kératosiques apparaissant sur la peau chroniquement exposée au soleil sous l'effet des rayons ultraviolets. Elles correspondent à une prolifération de kératinocytes atypiques limitée à l'épiderme et sont susceptibles de progression vers le carcinome épidermoïde in situ et le carcinome épidermoïde cutané (CEC). S'il est faible, le risque métastatique associé au CEC ne doit pas pour autant être négligé. Le concept de champ de cancérisation a été introduit en 1953 à la suite d'études de lésions néoplasiques de la muqueuse buccale. Il est défini comme une zone prétumorale d'aspect normal, comportant des anomalies infracliniques multifocales qui peuvent faire le lit de nouvelles lésions néoplasiques. De tels champs sont fréquents dans les zones cutanées photo-exposées et en périphérie des KA et des CEC. Dans cette situation, le traitement ne devrait pas se limiter aux lésions visibles ou palpables de KA et, en cas de suspicion de champ de cancérisation, un traitement visant à la destruction physique ou à l'élimination des kératinocytes atypiques de la totalité de la zone devrait être envisagé. Une telle approche pourrait en théorie améliorer le pronostic à long terme en diminuant l'émergence de nouvelles lésions, voire diminuer le coût économique global lié à la prise en charge des KA et optimiser l'aspect cosmétique du champ de cancérisation ; cela mérite, cependant, d'être confirmé.
Summary
Lesions occurring in actinic keratoses (AK) form erythematous, squamous, crusty and keratotic papules that appear on skin chronically exposed to the sun due to ultraviolet radiation. They are formed by the proliferation of atypical keratinocytes limited to the epidermis and may progress to squamous cell carcinoma in situ and to cutaneous squamous cell carcinoma (CEC). Although low, the metastatic risk associated with the CEC is not negligible. The concept of field cancerization was introduced in 1953 following studies of neoplastic lesions of the oral mucosa. A cancer field is a normal-looking pre-tumoral zone with subclinical, multifocal anomalies, which may constitute a base for new neoplastic lesions. Such fields are frequently seen in areas of photo-exposed skin and around the edges of AK and CEC. In this event, treatment should not be limited to visible or palpable AK lesions, and if a cancer field is suspected, treatment involving the physical destruction or elimination of atypical keratinocytes from the entire area should be considered. Such an approach may improve the long-term prognosis, reduce treatment costs and ensure optimal cosmetic outcome.
Antioxidant Properties of Ferulic Acid and Its Possible Application
Ferulic acid has low toxicity and possesses many physiological functions (anti-inflammatory, antioxidant, antimicrobial activity, anticancer, and antidiabetic effect). It has been widely used in the pharmaceutical, food, and cosmetics industry. Ferulic acid is a free radical scavenger, but also an inhibitor of enzymes that catalyze free radical generation and an enhancer of scavenger enzyme activity. Ferulic acid has a protective role for the main skin structures: keratinocytes, fibroblasts, collagen, elastin. It inhibits melanogenesis, enhances angiogenesis, and accelerates wound healing. It is widely applied in skin care formulations as a photoprotective agent, delayer of skin photoaging processes, and brightening component. Nonetheless, its use is limited by its tendency to be rapidly oxidized.
Skin Pharmacol Physiol 2018;31:332–336
Validated Patient-Reported Outcome Measurements for Psoriasis may not Reflect Patients’ Current Preferences
Publication date: Available online 20 September 2018
Source: Journal of the American Academy of Dermatology
Author(s): Oluwatobi Ogbechie-Godec, Sarah Azarchi, Jasmine Lee, David E. Cohen, Andrea Neimann, Arielle R. Nagler
Lack of an FDA indication should not limit access to appropriate treatment
Publication date: Available online 20 September 2018
Source: Journal of the American Academy of Dermatology
Author(s): Joerg Albrecht, Adewole S. Adamson, John Barbieri, Daniel D. Bennett, Elizabeth A. Kiracofe, A. Shadi Kourosh, Kieron S. Leslie, Joseph F. Merola, Josephine Nguyen, Elaine Siegfried, Nicole Strickland, Suzanne Olbricht, Maryam M. Asgari, AADA Task Force on Drug Pricing and Transparency
A population-based registry study on relative survival from melanoma in Germany stratified by tumor thickness for each histological subtype
Publication date: Available online 20 September 2018
Source: Journal of the American Academy of Dermatology
Author(s): Alicia Brunssen, Lina Jansen, Nora Eisemann, Annika Waldmann, Janick Weberpals, Klaus Kraywinkel, Andrea Eberle, Bernd Holleczek, Sylke Ruth Zeissig, Hermann Brenner, Alexander Katalinic, GEKID Cancer Survival Working Group
Abstract
Background
Differences in melanoma relative survival (RS) between histologies were discussed to be mainly caused by tumor thickness.
Objective
To investigate RS from melanoma, stratified by tumor thickness for each histological subtype, and identify survival trends.
Methods
Using cancer registry data on melanoma cases (ICD-10: C43.0-C43.9) diagnosed in Germany in 1997-2013, 5- and 10-year age-standardized RS stratified by histology and stratified or standardized by T-stage was estimated using standard and modelled period analyses. We restricted 10-year RS analyses to patients younger than 75 years.
Results
We analyzed 82,901 cases. Overall, 5- and 10-year RS was 91.7% and 90.8%, respectively. Prognosis worsened with increasing T-stage for all histologies but T-stage distribution varied substantially. Survival differences by histology were strongly alleviated after adjustment for T-stage, but remained significant. Overall, 5-year RS increased significantly by 3.8 percentage points between 2002-2005 and 2010-2013. This increase was no longer seen after adjustment for T-stage.
Limitations
Exclusion of cases due to missing information on T-stages, changes in the definition of T-stages, and lack of information on screening and treatment limit our analyses.
Conclusion
Differences in RS between histologies were strongly mediated by tumor thickness. Over time, melanoma RS increased due to changes in T-stage distribution.
Clinical and dermoscopic features of cutaneous BAP1 inactivated melanocytic tumors: results of a multicenter case-control study by the International Dermoscopy Society (IDS)
Publication date: Available online 20 September 2018
Source: Journal of the American Academy of Dermatology
Author(s): Oriol Yélamos, Cristián Navarrete-Dechent, Michael A. Marchetti, Tova Rogers, Zoe Apalla, Philippe Bahadoran, Nuria Blázquez-Sánchez, Klaus Busam, Cristina Carrera, Stephen W. Dusza, Arnaud de la Fouchardière, Gerardo Ferrara, Pedram Gerami, Harald Kittler, Aimilios Lallas, Josep Malvehy, José F. Millán-Cayetano, Kelly C. Nelson, Victor Li Quan, Susana Puig
Abstract
Background
Multiple BAP-1 inactivated melanocytic tumors (BIMTs) have been associated with a familial cancer-syndrome involving germline mutations in BAP1.
Objectives
We sought to describe the clinical and dermoscopic features of BIMTs.
Methods
Retrospective, multicenter, case-control study. Participating centers clinical data, dermoscopic images, and histopathological data of biopsy-proven BIMTs. We compared the dermoscopic features between BIMTs and controls.
Results
The dataset consisted of 48 BIMTs from 31 patients (22 females, median age=37 years), and 80 controls. Eleven patients had a BAP1 germline mutation. Clinically, most BIMTs presented as pink, dome-shaped papules (n=24). Dermoscopically, we identified 5 patterns: structureless pink-to-tan with irregular eccentric dots/globules (n=14, 29.8%); structureless pink-to-tan with a peripheral vessels (n=10, 21.3%); structureless pink-to-tan (n=7, 14.9%); network with raised, structureless, pink-to-tan areas (n=7, 14.9%); and globular pattern (n=4, 8.5%). The structureless with eccentric dots/globules pattern and network with raised structureless areas pattern were only identified in BIMT and were more common in patients with BAP1 germline mutations (p<0.0001 and p=0.001, respectively)
Limitations
Small sample size, retrospective design, absence of germline genetic testing in all patients, inclusion bias towards more atypical-looking BIMTs.
Conclusion
Dome-shaped papules with pink-to-tan structureless areas and peripheral irregular dots/globules or network should raise suspicion for BIMT.
A Provider Global Assessment Quality Measure for Clinical Practice for Inflammatory Skin Disorders
Publication date: Available online 20 September 2018
Source: Journal of the American Academy of Dermatology
Author(s): International Dermatology Outcome Measures and the American Academy of Dermatology, Alice Gottlieb, Nicole Salame, April W. Armstrong, Joseph F. Merola, Sylvia Parra, Junko Takeshita, Suephy C. Chen, John Latella, Marta Van Beek
Abstract
In our evolving healthcare system, dermatologists are increasingly being asked to prove the value of care they provide to patients with severe skin diseases. Current quality measures for inflammatory dermatoses have limited validity and feasibility. Through collaboration and a modified Delphi process, the International Dermatology Outcome Measures (IDEOM) group and American Academy of Dermatology (AAD) sought to reach consensus on a valid and feasible provider-assessed global disease severity metric to be incorporated into a quality measure for inflammatory dermatoses. To inform the modified Delphi process, a review of the literature was performed, and data was collected on current provider-assessed global disease severity metrics. Following literature review, 36 members of IDEOM and the AAD participated in the modified Delphi process to reach consensus on features of the metric. Psoriasis, atopic dermatitis, and acne achieved overwhelming consensus for inflammatory dermatoses that could be measured in a global disease severity metric. Consensus was also reached on the utilization of a 5-point ordinal scale with descriptors provided through referenced electronic platforms. Expert development of quality measures incorporating this metric and its inclusion in data collection platforms are critical to enabling dermatologists to prove the value of care provided to patients with severe inflammatory dermatoses.
Clinical outcomes in high-risk squamous cell carcinoma patients treated with Mohs micrographic surgery alone
Publication date: Available online 20 September 2018
Source: Journal of the American Academy of Dermatology
Author(s): Gerardo Marrazzo, John A. Zitelli, David Brodland
Abstract
Background
There is little evidence to predict patient outcomes following the treatment of high risk cutaneous SCC (hrSCC) using Mohs micrographic surgery (MMS).
Objective
To report the rates of poor outcomes in patients with hrSCC treated by MMS alone, and determine if any specific clinical factors may be more predictive of these outcomes.
Methods
We conducted a retrospective chart review of all hrSCC patients treated in our clinic from October 2011 to December 2015.
Results
We identified 647 hrSCC tumors that met inclusion criteria. During the follow-up period, there were 19 local recurrences(LR) (2.9%), 31 nodal metastases(NM) (4.8%), 7 distant metastases(DM) (1.1%), and 7 disease-specific deaths(DSD) (1.1%). Two factors, poor differentiation and invasion beyond the subcutaneous fat, were positively associated with local recurrence, nodal metastasis, and disease-specific death through multivariate analysis.
Conclusions
Invasion beyond subcutaneous fat and poor histologic differentiation may carry a greater risk of poor outcomes than other factors in hrSCC. Mohs surgery alone provides excellent marginal control with low rates of local recurrence, nodal metastasis and disease-specific death.
Rethinking the classification of alopecia areata
Publication date: Available online 20 September 2018
Source: Journal of the American Academy of Dermatology
Author(s): C.G. Wambier, B.A. King
Comment on Okhovat et al “The first 30 years of the American Academy of Dermatology skin cancer screening program: 1985-2014”
Publication date: Available online 20 September 2018
Source: Journal of the American Academy of Dermatology
Author(s): Dayoung Ko, Shari R. Lipner
Platelet rich plasma as an adjunctive treatment in Lichen Plano pilaris
Publication date: Available online 20 September 2018
Source: Journal of the American Academy of Dermatology
Author(s): Abhijeet Kumar Jha
Reflectance confocal microscopy as novel tool for pre-surgical identification of basal cell carcinoma biopsy site
Publication date: Available online 20 September 2018
Source: Journal of the American Academy of Dermatology
Author(s): Cristián Navarrete-Dechent, Shoko Mori, Miguel Cordova, Kishwer S. Nehal
Dermoscopy of Pityrosporum Folliculitis
Publication date: Available online 20 September 2018
Source: Journal of the American Academy of Dermatology
Author(s): Deepak Jakhar, Ishmeet Kaur, Richa Chaudhary
Global Epidemiology and Clinical Spectrum of Rosacea, Highlighting Skin of Color: Review and Clinical Practice Experience
Publication date: Available online 19 September 2018
Source: Journal of the American Academy of Dermatology
Author(s): Andrew F. Alexis, Valerie D. Callender, Hilary E. Baldwin, Seemal R. Desai, Marta I. Rendon, Susan C. Taylor
Abstract
Among individuals with skin of color, rosacea has been reported less frequently than in those with white skin, but it is not a rare disease. In fact, rosacea may be underreported and underdiagnosed in populations with skin of color because of the difficulty of discerning erythema and telangiectasia in dark skin, as well as underestimation of the susceptibility of more highly pigmented skin to dermatologic conditions like rosacea whose triggers include sun exposure. Many people with skin of color who have rosacea may experience delayed diagnosis leading to inappropriate or inadequate treatment, greater morbidity, and uncontrolled, progressive disease with disfiguring manifestations, including phymatous rosacea. This paper reviews the epidemiology of rosacea in skin of color and highlights variations in the clinical presentation of rosacea across the diverse spectrum of patient populations affected. It presents strategies to aid in the timely diagnosis and effective treatment of rosacea in patients with skin of color, with an aim of promoting increased awareness of rosacea in these patients and reducing disparities in the management of their disease.
Radiotherapy‐induced Pemphigus Foliaceous: a rare adverse effect of breast cancer therapy
International Journal of Dermatology, EarlyView.
Pseudodidymosis: nevus psiloliparus with aplasia cutis congenita, an initial manifestation of Haberland syndrome
International Journal of Dermatology, EarlyView.
Clinical use of dimethyl fumarate in moderate‐to‐severe plaque‐type psoriasis: a European expert consensus
Journal of the European Academy of Dermatology and Venereology, EarlyView.
Increased immunoreactivity of TRPM8 in cutaneous squamous cell carcinoma
Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.
Are Descriptions Really Descriptive? An Experimental Study on Misdescription and Reference
Abstract
This paper presents an experimental study on definite descriptions. According to the classical views, a definite description, i.e., a phrase of the form "the F", has – roughly speaking - purely descriptive semantics, that is, it designates the object which uniquely (opt. uniquely in a context) satisfies the description. However, as several philosophers including Keith Donnellan have argued, there are uses of definite descriptions on which these expressions do not seem to designate objects which satisfy the descriptions. Namely, a description may refer in some circumstances to an object which does not have the property from the description. This argument is called "the Argument from misdescription" and it is raised against the classical views on the semantics of definite descriptions. In our paper, we present an experimental study on misdescription and explored reactions of ordinary users of language to various statements involving misdescriptions. The results of our research indicate that the intuition of ordinary speakers is consistent with the prediction expressed in the Argument from misdescription. We argue that the most common pragmatic explanation of misdescription, appealing to Gricean distinction between saying and meaning, is unconvincing. We vote for an alternative semantic account of definite descriptions, on which a description "the F" designates an object being F, which is at the same time the most salient individual according to a contextually established ranking of salience.
SnapshotDx Quiz: October 2018
Editorial note: Welcome to the Journal of Investigative Dermatology (JID) SnapshotDx Quiz. In this monthly online-only quiz, the first question ("What is your diagnosis?") relates to the clinical images above, while additional questions concern the findings reported in the JID article by Lauffer et al (https://ift.tt/2xBBOLj).
Topical Antiseptics and the Skin Microbiota
The impact of antiseptics on the skin microbiota is poorly understood. SanMiguel et al. (2018) use a sequencing-based approach to compare treatment effects and find that they are dependent on interpersonal and body site–specific community differences. While treatment results in an immediate depletion of the skin microbiota, not all bacterial families are affected equally.
Automated Classification of Skin Lesions: From Pixels to Practice
The letters "Interpretation of the Outputs of Deep Learning Model trained with Skin Cancer Dataset" and "Automated Dermatological Diagnosis: Hype or Reality?" highlight the opportunities, hurdles, and possible pitfalls with the development of tools that allow for automated skin lesion classification. The potential clinical impact of these advances relies on their scalability, accuracy, and generalizability across a range of diagnostic scenarios.
Cells to Surgery Quiz: October 2018
Editorial note: Welcome to the Journal of Investigative Dermatology (JID) Cells to Surgery Quiz. In this monthly online-only quiz, the first question ("What is your diagnosis?") relates to the clinical image above, while additional questions concern the findings reported in a JID article by Miller et al (https://ift.tt/2QJo8X8).
Research Techniques Are Not Simple
"Education is not the filling of a pail, but the lighting of a fire."—W.B. Yeats
The Value and Process of Authoring a “Research Techniques Made Simple” Article
The "Research Techniques Made Simple" (RTMS) series has covered nearly 75 research topics in the past 6 years to help readers build a foundation from which to understand the vast array of basic science and clinical research tools used in the field of dermatology. The early RTMS articles published in late 2012 through 2014 covered fundamental techniques including flow cytometry (Jahan-Tigh et al., 2012), PCR (Garibyan and Avashia, 2013), how a transgenic mouse is made (Scharfenberger et al., 2014), and basics of systematic reviews and meta-analyses (Abuabara et al., 2012).
Building on a Solid Foundation
The JID Connector was established to do just that—connect. It was in that spirit that "Research Techniques Made Simple" (RTMS) was born. The initial concept, conceived by Barbara Gilchrest of Harvard University and implemented by Kathy Schwarzenberger of the University of Tennessee Health Science Center, was to increase the accessibility of articles that appeared in the Journal of Investigative Dermatology (JID). It was recognized, however, that to reach trainees, interested clinicians, and non-cognoscenti, the science had to be more accessible and understandable.
Research Techniques Made Simple: Animal Models of Wound Healing
Animal models have been developed to study the complex cellular and biochemical processes of wound repair and to evaluate the efficacy and safety of potential therapeutic agents. Several factors can influence wound healing. These include aging, infection, medications, nutrition, obesity, diabetes, venous insufficiency, and peripheral arterial disease. Lack of optimal preclinical models that are capable of properly recapitulating human wounds remains a significant translational challenge. Animal models should strive for reproducibility, quantitative interpretation, clinical relevance, and successful translation into clinical use.
Editors’ Picks
Vitiligo results from CD8+ T cell targeting of melanocytes, leading to patchy depigmentation. Upon cessation of therapy, depigmentation recurs at the same locations, implicating resident autoimmune memory T (TRM) cells. Indeed, Richmond and colleagues found that vitiligo patients have antigen-specific autoreactive TRM cells in lesional skin. As interleukin (IL)-15 is critical for generation of TRM cells, these investigators examined the effects of blocking IL-15 signaling via an antibody to the IL-15 CD122 subunit, which is expressed on autoreactive TRM cells in vitiligo.
Clinical Snippets
Simpson and colleagues examined the clinical and physiological features and serum biomarkers in adult atopic dermatitis (AD) patients with and without Staphylococcus aureus colonization. AD patients colonized by S. aureus exhibited a distinct clinical phenotype and endotype, marked by more severe disease, greater epidermal function impairment, more pronounced defects in permeability and skin hydration, increased immune activation, type 2 immunity, and more extensive tissue damage than non-AD patients colonized by S. aureus.
IL-22 downregulates Cx43 expression and decreases gap junctional intercellular communication by activating the JNK pathway in psoriasis
The roles of interleukin-22 (IL-22) in the pathomechanisms of psoriasis have been well demonstrated. Gap junctional intercellular communication (GJIC) is widely known for its involvement in multiple biological and pathological processes such as growth-related events, cell differentiation, and inflammation. Here, we show that IL-22 significantly decreased GJIC and downregulated Cx43 expression in HaCaT cells. Cx43 overexpression markedly inhibited the proliferation of and increased GJIC in HaCaT cells, while the silencing of Cx43 exerted the opposite effects.
Vaccinating against Acne: Benefits and Potential Pitfalls
Acne vulgaris is treated with antibiotics and retinoids, but side effects are numerous. Novel safe and efficient therapies are still needed. Wang et al. demonstrate that the secreted virulence factor Christie-Atkins-Munch-Peterson factor 2 from Propionibacterium acnes, a bacterium involved in acne pathogenesis, promotes inflammatory responses. This proinflammatory property could be inhibited by antibodies to Christie-Atkins-Munch-Peterson factor 2, suggesting Christie-Atkins-Munch-Peterson factor 2 as a candidate target in acne vaccination.
Revisiting the clinical and biologic relevance of partial PTEN loss in melanoma
The extent of PTEN loss that confers clinical and biological impact in melanoma is unclear. We evaluated the clinical and biologic relevance of PTEN dosage in melanoma, and tested the postulate that partial PTEN loss is due to epigenetic mechanisms. PTEN expression was assessed by immunohistochemistry in a stage III melanoma cohort (n=190) with prospective follow up. 21/190 (11%) of tumors had strong PTEN expression, 51/190 (27%) had intermediate PTEN, 44/190 (23%) had weak PTEN, and 74/190 (39%) had absent PTEN.
Exosomes in HNSCC plasma as surrogate markers of tumour progression and immune competence
Clinical &Experimental Immunology, EarlyView.
High MDR‐1 expression by MAIT cells confers resistance to cytotoxic but not immunosuppressive MDR‐1 substrates
Clinical &Experimental Immunology, EarlyView.
How millennials could impact the evolution of wound care
International Wound Journal, Volume 15, Issue 5, Page 681-682, October 2018.
Ultraviolet B induced immunosuppression is not associated with RANKL upregulation in human skin
Photodermatology, Photoimmunology &Photomedicine, Volume 0, Issue ja, -Not available-.
Intestinal microbiota profiling and predicted metabolic dysregulation in psoriasis patients
Experimental Dermatology, Volume 0, Issue ja, -Not available-.
HIF‐1α‐mediated BMP6 down‐regulation leads to hyperproliferation and abnormal differentiation of keratinocytes in vitro
Experimental Dermatology, Volume 0, Issue ja, -Not available-.
Down‐regulated SHARPIN may accelerate the development of atopic dermatitis through activating interleukin‐33/ST2 signaling
Experimental Dermatology, Volume 0, Issue ja, -Not available-.
Size‐dependent Tumor Response to Photodynamic Therapy and Irinotecan Monotherapies Revealed by Longitudinal Ultrasound Monitoring in an Orthotopic Pancreatic Cancer Model
Photochemistry and Photobiology, Volume 0, Issue ja, -Not available-.
Trachelas tranquillus envenomation with presumed bacterial superinfection in a child
Pediatric Dermatology, EarlyView.
Epidemiology of pyoderma gangrenosum in Japanese patients by questionnaire survey
The Journal of Dermatology, EarlyView.
Distant recurrence of Merkel cell carcinoma after spontaneous regression
The Journal of Dermatology, EarlyView.
Primary cutaneous diffuse large B‐cell lymphoma, leg type, localized in the right periorbital region
The Journal of Dermatology, EarlyView.
Anti‐PL‐12 antibody‐positive antisynthetase syndrome with recurrent digital ulcers
The Journal of Dermatology, EarlyView.
Bone scintigraphy analysis of 44 cases of pustulotic arthro‐osteitis associated with palmoplantar pustulosis
The Journal of Dermatology, EarlyView.
Acneiform eruptions: An unusual dermatological side effect of ribavirin
Dermatologic Therapy, EarlyView.
When side effect becomes the effect: Efficacy of capecitabine in refractory psoriasis
Dermatologic Therapy, EarlyView.
Successful treatment of erythrodermic pityriasis rubra pilaris with acitretin
Dermatologic Therapy, EarlyView.
Risk of first‐time and recurrent depression in patients with psoriasis – a population‐based cohort study
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
Subtype‐Specific Inherited Predisposition to Pemphigus in Chinese Population
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
Psoriasin (S100A7) and koebserisin (S100A15) as potential markers of atherosclerosis in patients with psoriasis
Clinical and Experimental Dermatology, EarlyView.
Multiple rapidly growing necrotic eruptions on the face
Clinical and Experimental Dermatology, EarlyView.
Uncommon low-grade brain tumors
Abstract
The 2016 WHO classification of primary central nervous system (CNS) tumors include numerous uncommon (representing ≤1% of tumors) low-grade (grade I-II) brain neoplasms with varying clinical behaviors and outcomes. Generally, gross tumor or maximal safe resection is the primary treatment. Adjuvant treatments, though their exact role is unknown, may be considered individually based on pathological subtypes and a proper assessment of risks and benefits. Targetable mutations such as BRAF, TRAIL, and PDGFR etc. have a promising role in the future management. Search strategy and selection criteria
An initial search of PubMed used broad search terms 'brain tumors', 'low-grade', 'radiotherapy, 'chemotherapy', 'surgery' and 'treatment' from January 1990 to March 2018. A subsequent focused search was undertaken using the names of individual histological subtypes of low-grade brain tumors as in the 2016 WHO classification. Only papers published in English were reviewed. The final reference list was generated on the basis of originality and relevance to the broad scope of this review.Linear IgA bullous dermatosis presenting as chronic prurigo: unveiling of the diagnosis by serrated pattern analysis
International Journal of Dermatology, EarlyView.
Reflectance confocal microscopy of tinea capitis: comparing images with results of dermoscopy and mycological exams
International Journal of Dermatology, EarlyView.
Multiple “halo nevi” occurring during pembrolizumab treatment for metastatic melanoma
International Journal of Dermatology, EarlyView.
Predicting risk for seroma development after axillary or inguinal sentinel lymph node biopsy in melanoma patients
International Journal of Dermatology, EarlyView.
Plasma cell vulvitis: further confirmation of the diagnostic utility of dermoscopy
International Journal of Dermatology, EarlyView.
Asymptomatic indurated plaque on the tongue in an immunocompetent man
International Journal of Dermatology, EarlyView.
Aversion caused by skin diseases – a crowdsourcing study
International Journal of Dermatology, EarlyView.
Expression and significance of phosphodiesterase 4B gene in peripheral blood of patients with oral lichen planus
International Journal of Dermatology, EarlyView.
Cutaneous effects associated with fluconazole in patients treated for coccidioidomycosis
International Journal of Dermatology, EarlyView.
Cutaneous collagenous vasculopathy induced by the vascular endothelial growth factor receptor inhibitor axitinib
International Journal of Dermatology, EarlyView.
Mutation in the SR6 region of desmoplakin is associated with pustular psoriasiform rash and left ventricular dysfunction
International Journal of Dermatology, EarlyView.
Lymphoepithelioma‐like carcinoma of the skin: a possible culprit when biopsy indicates a benign inflammatory reaction
International Journal of Dermatology, EarlyView.
A novel cognitive stress management technique for acne vulgaris: a short report of a pilot experimental study
International Journal of Dermatology, EarlyView.
Evaluation of lead release potential of new premise plumbing materials
Abstract
Premise plumbing materials such as pipes, valves, fittings, and faucets are made of various materials, including plastic, stainless steel, copper, and brass/bronze. Although lead pipe has been banned for its use in drinking water supply by most countries in the 1980s, lead is still commonly used as an additive in many plumbing materials for its flexibility and malleability. Certified leaching tests for plumbing materials are usually conducted using relatively mild solutions over short periods which may not reveal the true risk of lead exposure when these materials are used. The objective of this study is to investigate the extents of lead release from commonly used premise plumbing materials into drinking water. The maximum lead leaching potential for pluming material was operationally determined using high strength acidic EDTA solutions (pH 4, EDTA = 100 mg/L) for a stagnation time of 3 days for a total period of up to 1 month. Lead leaching from each plumbing material was also evaluated using reconstituted tap water. Brass- and bronze-based plumbing materials were found to release dangerous levels of lead. Surface lead weight percentage obtained using SEM-EDX and lead weight percentages of the material body obtained using strong acid digestion were found to positively correlate with lead release. A re-examination of the appropriateness of current certified leaching tests and a more stringent regulation on the use of lead as an additive for plumbing materials should be considered.
Removal of fluoride by carbohydrate-based material embedded with hydrous zirconium oxide nanoparticles
Abstract
Herein, we fabricated a novel carbohydrate-based adsorbent by using the pomelo peel (PP) as the biocarrier. The virgin PP was embedded with hydrous zirconium oxide (HZO) nanoparticle, forming the HZO-PP composites for highly efficient fluoride adsorption. Characteristics of HZO-PP were determined by TEM, SEM, XPS, XRD, BET surface area, and FTIR. The result showed that HZO nanoparticles have been successfully anchored onto the inner pore of PPs, which play a significant role in defluorination. It is favorable for fluoride uptake with more acidic solution, which greatly enhanced the interfacial reaction between the fluoride ions and protonated HZO through electrostatic interaction or electro-dipole interaction. No significant Zr leaching and organic dissolution were observed within pH 3.0–11.0; this indicated the strong interfacial reaction between the biocarrier and HZO, which illustrated the high stability of the HZO-PP for use. Competing tests indicated that fluoride uptake by HZO-PP still retained about 76–88% as the concentrations of coexisting NO3− or SO42− was 25 times higher than that of F−. The HZO-PP in column after six adsorption-regeneration cycles still retained 94% of adsorption capacity (15.4 mg/g). All these results implied that biomaterials anchored with multivalent metal oxides represented the potential nanocomposites for fluoride removal.
Pollution and energy reduction strategy in soft drink industries
Abstract
The present study was conducted on soft drink industry with the objective to reduce wastewater pollution through end-of-pipe treatment and controlling energy loss through steam pipeline insulation approach. For this purpose, the main operation and manufacturing steps were examined. Wastewater was analyzed for 10 physicochemical parameters. Among these parameters, total dissolved solids (TDS), total suspended solids (TSS) and chemical oxygen demand (COD) were above their permissible level of Pakistan national environmental quality standards (Pak NEQS). For wastewater treatment, sedimentation, flocculation, coagulation and adsorption were tested. The active study reduces the pollution load up to 48%. After treatment, all the parameters were below the Pak NEQS level. To reduce the energy loss and economic benefits, the steam pipeline system was galvanized using glass wool, sheet and paper. Through galvanizing, 91.4% of energy was recovered and reduced an extra cost of 91.5%. The net saving of energy and cost are 312 GJ and114098 Rs/year, respectively. The study recommends end off pipe treatment and insulation of bare pipeline system for soft drink industries.
CaO-based sorbent derived from lime mud and bauxite tailings for cyclic CO 2 capture
Abstract
Using aluminum nitrate (AlN) and bauxite tailings (BTs) as different dopants, and lime mud (LM) as calcium source, a series of CaO-based sorbents were prepared for CO2 capture by dry mixing method; then, the carbonation conversions of multiple carbonation/calcination cycles were detected in a thermogravimetric analyzer (TGA). Effects of different dopants, dopant contents, precalcination conditions, and a long series of cycles on CO2 absorption properties were scrutinized, and the phase composition and morphologies were tested by scanning electron microscopy (SEM) and X-ray diffraction (XRD). Durability studies show that the sample doped with AlN remains a higher absorption conversion (30.88%) after 30 carbonation/calcination cycles. In the meantime, the sorbent doped with BTs showed a lower conversion, which is probably resulted from the impurities from waste BTs. However, the sample BT has a better cyclic absorption stability. In addition, the incorporation of BTs, as a kind of solid waste, not only decreases the preparation cost but also is good for environment. The occurrence of Ca12Al14O33 phase is considered to provide a stable framework inhibiting inactivation of CaO, and improve the CO2 adsorption stability.
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A Case of Diprosopus Tetraophthalmos: Ocular Findings and Surgical Treatment of Exposure KeratopathyDiprosopus is a rare variation of conjoined twinning. In this report, ophthalmic findings in an infant with diprosopus tetraophthalmos are p...
