Clinical Snippets

Simpson and colleagues examined the clinical and physiological features and serum biomarkers in adult atopic dermatitis (AD) patients with and without Staphylococcus aureus colonization. AD patients colonized by S. aureus exhibited a distinct clinical phenotype and endotype, marked by more severe disease, greater epidermal function impairment, more pronounced defects in permeability and skin hydration, increased immune activation, type 2 immunity, and more extensive tissue damage than non-AD patients colonized by S. aureus.