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Vitiligo results from CD8+ T cell targeting of melanocytes, leading to patchy depigmentation. Upon cessation of therapy, depigmentation recurs at the same locations, implicating resident autoimmune memory T (TRM) cells. Indeed, Richmond and colleagues found that vitiligo patients have antigen-specific autoreactive TRM cells in lesional skin. As interleukin (IL)-15 is critical for generation of TRM cells, these investigators examined the effects of blocking IL-15 signaling via an antibody to the IL-15 CD122 subunit, which is expressed on autoreactive TRM cells in vitiligo.