Role of circular RNAs in osteoarthritis (Review)

xlomafota13 shared this article with you from Inoreader Role of circular RNAs in osteoarthritis (Review) Via Experimental and therapeutic medicine Exp Ther Med. 2021 Nov;22(5):1279. doi: 10.3892/etm.2021.10714. Epub 2021 Sep 9. ABSTRACT Osteoarthritis (OA) is a chronic bone and joint disease characterized by articular cartilage degeneration and joint inflammation. OA is the most common form of arthritis, and the major clinical manifestations of OA are chronic pain and joint activity disorder, which severely affect patients' quality of life. Circular RNA (circRNA) is a type of non-coding RNA that is ubiquitous in eukaryotic cells. Unlike standard linear RNAs, they form a covalently closed continuous loop without 5' or 3' polarity. They are usually considered as byproducts of mis-splicing or mRNA processing. CircRNAs have been detected and identified in numerous species. Various studies have confirmed that certain circRNAs are differentially expressed in OA cartilage and are closely associated with a variety of pathological processes of OA, including extracellular matrix degradatio n, inflammation and apoptosis. The present study reviewed the latest research on circRNAs in the pathogenesis of OA, providing a novel direction for the prevention, diagnosis and treatment of OA. PMID:34594416 | PMC:PMC8456490 | DOI:10.3892/etm.2021.10714 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.