Hyperthyroidism in adolescents

xlomafota13 shared this article with you from Inoreader Hyperthyroidism in adolescents Via radioactive iodine Endocr Connect. 2021 Oct 1:EC-21-0191.R1. doi: 10.1530/EC-21-0191. Online ahead of print. ABSTRACT The term 'hyperthyroidism' refers to a form of thyrotoxicosis due to inappropriately high synthesis and secretion of thyroid hormone(s) by the thyroid. The leading cause of hyperthyroidism in adolescents is Graves' disease (GD); however, one should also consider other potential causes, such as toxic nodular goiter (single or multinodular) and other rare disorders leading to excessive production and release of thyroid hormones. The term 'thyrotoxicosis' refers to a clinical state resulting from inappropriately high thyroid hormone action in tissues, generally due to inappropriately high tissue thyroid hormone levels. Thyrotoxicosis is a condition with multiple aetiologies, manifestations, and potential modes of therapy. By definition, the extrathyroidal sources of excessive amounts of thyroid hormones, such as iatrogenic thyrotoxicosis, factitious ingestion of thyroid hormone, or struma ovarii, do not include hyperthyroidism. The aetiology of hyperthyroidism/and thyrotoxicosis should be determined. Although the diagnosis is apparent based on the clinical presentation and initial biochemical evaluation, additional diagnostic testing is indicated. This testing should include (1) measurement of TSHR antibodies (TRAb); (2) analysis of thyroidal echogenicity and blood flow on ultrasonography; or (3) determination of radioactive iodine uptake (RAIU). A 123I or 99mTc pe rtechnetate scan is recommended when the clinical presentation suggests toxic nodular goiter. Different treatment modalities might be preferred to achieve euthyroidism and to avoid potential risks from the treatment. The vast majority of patients with thyroid disorders require life-long treatment; therefore, the collaboration of different specialists is warranted to achieve these goals and improve patients' quality of life. PMID:34596580 | DOI:10.1530/EC-21-0191 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.