Role of protein phosphatase 2A in kidney disease (Review)

xlomafota13 shared this article with you from Inoreader Role of protein phosphatase 2A in kidney disease (Review) Via Experimental and therapeutic medicine Exp Ther Med. 2021 Nov;22(5):1236. doi: 10.3892/etm.2021.10671. Epub 2021 Aug 31. ABSTRACT Kidney disease affects millions of people worldwide and is a financial burden on the healthcare system. Protein phosphatase 2A (PP2A), which is involved in renal development and the function of ion-transport proteins, aquaporin-2 and podocytes, is likely to serve an important role in renal processes. PP2A is associated with the pathogenesis of a variety of different kidney diseases including podocyte injury, inflammation, tumors and chronic kidney disease. The current review aimed to discuss the structure and function of PP2A subunits in the context of kidney diseases. How dysregulation of PP2A in the kidneys causes podocyte death and the inactivation of PP2A in renal carcinoma tissues is discussed. Inhibition of PP2A activity prevents epithelial-mesenchymal transition and attenuates renal fibrosis, creating a favorable inflammatory microenvironm ent and promoting the initiation and progression of tumor pathogenesis. The current review also indicates that PP2A serves an important role in protection against renal inflammation. Understanding the detailed mechanisms of PP2A provides information that can be utilized in the design and application of novel therapeutics for the treatment and prevention of renal diseases. PMID:34539832 | PMC:PMC8438693 | DOI:10.3892/etm.2021.10671 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.