IL-1α, IL-6 and IL-8 serum values in patients with chronic suppurative otitis media

xlomafota13 shared this article with you from Inoreader IL-1α, IL-6 and IL-8 serum values in patients with chronic suppurative otitis media Via Experimental and therapeutic medicine Exp Ther Med. 2021 Nov;22(5):1226. doi: 10.3892/etm.2021.10660. Epub 2021 Aug 27. ABSTRACT Inflammatory mediators play an important role in the pathogenesis of otitis media by initiating and maintaining an inflammatory response to infection. The presence of inflammatory mediators may be one of the reasons, in some patients, for acute otitis media transforming into chronic otitis media. The present study included 60 patients admitted to the Clinical Rehabilitation Hospital, Iasi, Romania, for surgery. The control group comprised 30 healthy individuals. Serum levels of interleukin 1α (IL-1α), interleukin 6 (IL-6) and interleukin 8 (IL-8) were measured prior to surgery and were compared among patients with chronic suppurative otitis media (CSOM), cholesteatoma and cholesteatoma recidivism and the control group. High serum levels of interleukins were recorded in all the groups compared to the healthy control group. IL-6 and IL-8 had the highest value in patients with CSOM and IL-1α had the highest value in patients with cholesteatoma recidivism. Thus, we can consider that inflammatory mediators play a central role in the pathogenesis of CSOM and cholesteatoma by maintaining a systemic and local inflammatory response. PMID:34539822 | PMC:PMC8438691 | DOI:10.3892/etm.2021.10660 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.