Tailoring the approach to radioactive iodine treatment in thyroid cancer

xlomafota13 shared this article with you from Inoreader Tailoring the approach to radioactive iodine treatment in thyroid cancer Via radioactive iodine Endocr Relat Cancer. 2021 Jul 1:ERC-21-0161.R1. doi: 10.1530/ERC-21-0161. Online ahead of print. ABSTRACT The treatment of differentiated thyroid cancer continues to move away from a 'one size fits all' approach to a process of tailored therapeutic decision-making that incorporates disease-specific factors and individual patient preferences. Management options range from active surveillance to thyroid lobectomy to total thyroidectomy with or without the use of postoperative radioac tive iodine (RAI). RAI may be administered for one or more reasons: Thyroid remnant ablation, adjuvant therapy, or therapy for persistent structural disease. It is important to be cognizant of the therapeutic intent of RAI and weigh the risks and benefits of treatment for each individual patient. Risk stratification should be used to identify those patients who are most likely to benefit from RAI and guide therapeutic choices. Available data suggest that RAI can be safely deferred for most patients considered at low risk for structural recurrence, while adjuvant RAI is associated with improved disease-free survival in patients with higher risk disease. Although progress has been made, many areas of uncertainty related to the use of RAI remain. These include: 1) The appropriate selection of intermediate risk patients to receive adjuvant RAI, 2) the superiority or inferiority of different RAI dosing activities, 3) the optimal approach to the use of RAI in special populations, includin g patients with ESRD and children and 4) the management of patients with RAI-refractory disease. PMID:34254949 | DOI:10.1530/ERC-21-0161 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.