Endoscopic treatment of cardia lesions: the effects on gastroesophageal reflux disease

xlomafota13 shared this article with you from Inoreader Endoscopic treatment of cardia lesions: the effects on gastroesophageal reflux disease Via Traditional dysphagia therapy Ann Palliat Med. 2021 Jun;10(6):6669-6677. doi: 10.21037/apm-21-1154. Epub 2021 Jun 10. ABSTRACT BACKGROUND: Drug treatment is the main form of management for patient with gastroesophageal reflux disease (GERD). However, long-term medication can increase the psychological burden of patients. Furthermore, in some patients, standardized drug treatments do not effectively control their condition. Traditional anti-reflux surgery has a low degree of acceptance due to its trauma and many associated complications. In contrast, endoscopic minimally invasive surgery is preferable. This study explored the effects of endoscopic treatment of cardia diseases on GERD. METHODS: A retrospective analysis was conducted on 106 patients with cardia disease (including cardia polyp, precancerous lesion, and early cardia cancer) and reflux esophagitis (RE). Patients underwent endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD), and th e rates of complete resection, postoperative complications, and postoperative reflux were assessed. RESULTS: Among the 106 lesions, 104 lesions were completely resected, and 2 early cancers were cured. No delayed hemorrhage was detected in any of the cases. The GERD-HRQL (gastroesophageal reflux disease-health related quality of life) and GERD-Q (gastroesophageal reflux disease-questionnaires) scores decreased significantly at 3 and 6 months post-operation (P<0.001). Furthermore, the RE grade was significantly different before and after the operation (P<0.001). The basic cure rate at 3 and 6 months after the operation was 83.96% and 84.91%, respectively, and the significant remission rate was 10.38% and 8.49%, respectively. CONCLUSIONS: Endoscopic treatment of cardia conditions is advantageous due to low levels of trauma, higher complete resection rates, and fewer complications. Moreover, the fibrous scar generated after endoscopic treatment forms an anti-reflux ba rrier, which can alleviate or even cure RE to a certain extent. This may represent a promising method for the clinical treatment of GERD. PMID:34154339 | DOI:10.21037/apm-21-1154 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.