Locally aggressive orbital giant cell reparative granuloma in an infant: case report and literature review

xlomafota13 shared this article with you from Inoreader Locally aggressive orbital giant cell reparative granuloma in an infant: case report and literature review Via International Journal of Clinical and Experimental Pathology Int J Clin Exp Pathol. 2021 Jun 15;14(6):776-781. eCollection 2021. ABSTRACT Giant cell reparative granuloma (GCRG) is a non-neoplastic hyperplasia of bones that mostly happens in the mandible and maxilla in any age group but has a predilection for children and young adults. GCRGs that cause bone destruction are of very low frequency. Orbital-involved cases have been rarely reported since 1981, especially in children. We now report a 1-year-old girl with a rapidly enlarging post-traumatic orbital mass. CT scan and surgical resection showed a well-defined mass occupying the upper right orbit, causing bone destruction. Microscopically there was a proliferation of histocytes and some osteoclast-like multinucleated giant cells with hemosiderin, finally confirmed to be GCRG. 22 months' follow up showed no evidence of recurrence. This case suggests infant orbital GCRG can be locally aggressive. PMID:34239680 | PMC:PMC8255204 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.