Association of single-nucleotide polymorphism on chromosome 9 and ischemic stroke in Heilongjiang province in China

xlomafota13 shared this article with you from Inoreader Association of single-nucleotide polymorphism on chromosome 9 and ischemic stroke in Heilongjiang province in China Via International Journal of Clinical and Experimental Pathology Int J Clin Exp Pathol. 2021 Jun 15;14(6):726-733. eCollection 2021. ABSTRACT There is a significant correlation between ischemic stroke (IS) and chromosome 9. However, its status was uncertain in China's cold regions. 1920 IS patients, and 1920 healthy individuals were included in the study. Blood samples were collected. The association of SNPs with IS was evaluated by Sequenom, and logistic regression models adjusted for known risk factors of IS were constructed to assess the SNPs' associations in cases and controls. We found rs1333040 and rs2383207 were associated with IS, compared with primitive genotypes. The genotype CT of rs7027526 has a protective role during IS development, while the effect of the genotype TT is still not clear. These results changed after stratification by age and sex. In conclusion, rs1333040 and rs2383207 SNPs in CDKN2BAS are associated with ischemic stroke in the Chinese Han population. This study confirms the association between 9p21.3 and IS. PMID:34239674 | PMC:PMC8255203 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.