Impact of Experience on Outcomes After Endoscopic Transsphenoidal Surgery for Acromegaly

xlomafota13 shared this article with you from Inoreader Impact of Experience on Outcomes After Endoscopic Transsphenoidal Surgery for Acromegaly Via leak of cerebrospinal fluid World Neurosurg. 2021 May 21:S1878-8750(21)00725-7. doi: 10.1016/j.wneu.2021.05.030. Online ahead of print. ABSTRACT OBJECTIVE: Acromegaly is a syndrome of metabolic alterations secondary to increased growth hormone levels from a somatotroph pituitary adenoma. A multidisciplinary approach beginning with surgery, followed by adjuvant radiation or medical therapy for residual disease, is considered standard of care. Several factors affect the likelihood of remission after surgery, but the impact of surgical experience on remission rates has not been adequately assessed. METHODS: Retrospective review of 203 patients, divided into 2 eras (era 1, 102 patients; era 2, 101 patients) of patients who underwent transsphenoidal surgery for acromegaly by a single surgeon over 11 years, was performed, determining the effect of surgical experience on rates of remission and various complications. Remission was defined according to the 2014 Endocrine S ociety Clinical Practice Guideline. RESULTS: The rate of surgical remission was 40.6% (62.9% among noninvasive adenomas). Rates of surgical remission significantly improved in the latter half of this cohort (31.2% in the first half vs. 50% in the second half), despite other factors being comparable. On multivariate analysis, surgeon experience, cavernous sinus invasion, and preoperative growth hormone levels affected the rates of surgical remission. Rates of cerebrospinal fluid leak and hypopituitarism were lower in the second half, whereas resolution of acromegaly-associated comorbidities was increased. CONCLUSIONS: We report, in this large single-surgeon review of endoscopically operated acromegaly cases, increased rates of surgical remission and reduced complications with increasing surgeon experience. The overall experience of the treating team in dealing with perioperative and intraoperative factors also contributes to improved outcomes. PMID:34023462 | DOI:10.1016/j.wneu.2021.05.030 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.