Association of vitamin D receptor gene polymorphisms in North Indian children with asthma: a case-control study

xlomafota13 shared this article with you from Inoreader Association of vitamin D receptor gene polymorphisms in North Indian children with asthma: a case-control study Via International Journal of Molecular Epidemiology and Genetics Int J Mol Epidemiol Genet. 2021 Apr 15;12(2):24-34. eCollection 2021. ABSTRACT Asthma is a complex genetic disease. Vitamin D and vitamin D receptor (VDR) gene polymorphisms are involved in asthma pathogenesis. However, accurate inflammatory mechanisms and their role in VDR gene polymorphisms are unclear. The objective of this study was to investigate the association of VDR gene polymorphisms, ApaI, FokI, TaqI, and BsmI with asthma as compared to controls. Children (age 5-15 years) with a history of respiratory symptoms (wheeze, shortness of breath and chest tightness) were recruited as cases. Age matched children admitted with central nervous system disorders (encephalitis/seizures) without any respiratory complaints were recruited as controls after parental consent. Children with a clinical diagnosis of cystic fibrosis, congenital heart disease and whose parents did not consent for par ticipation in the study were excluded. VDR gene polymorphisms were genotyped using PCR-RFLP method. One hundred and sixty asthmatics and one hundred controls were enrolled in this study. Mean age of the cases was 103.29±32.7 months and controls 94.24±30.52 months. Children with heterozygous (AC) genotype [OR=1.83, 95% CI=1.01-3.32, p=0.046] of ApaI polymorphism were found to be associated with the risk of asthma. Our findings suggest that ApaI polymorphism of VDR gene may contribute to asthma susceptibility among children. PMID:34093968 | PMC:PMC8166730 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.