The otolaryngologic manifestations of Sotos syndrome 1: A systematic review

xloma.fota.13 shared this article with you from Inoreader The otolaryngologic manifestations of Sotos syndrome 1: A systematic review Via International journal of pediatric otorhinolaryngology,http://goo.gl/4YdRhz Int J Pediatr Otorhinolaryngol. 2021 Apr;143:110649. doi: 10.1016/j.ijporl.2021.110649. Epub 2021 Feb 12. ABSTRACT OBJECTIVES: Sotos syndrome 1 (SOTOS1; MIM:117550) is rare genetic disorder characterized by excessive physical growth before and after birth, distinctive facial features, a large and elongated head, and intellectual disability (Sotos et al., 1964; Tatton-Brown et al., 1993). This systematic review aims to determine otolaryngologic conditions and complications of SOTOS1 based on existing literature through a review of current and past case reports and studies regarding SOTOS1. METHODS: A systematic review of all published literature (1964-2020) describing otolaryngologic conditions and/or complications of patients with SOTOS1. Twenty journal articles met inclusion criteria. These articles included 160 patients diagnosed with SOTOS1. RESULTS: Of the 160 individuals with SOTOS1 included in this review, 22 (14%) we re reported to have otologic conditions. 4 (3%) individuals were reported to have conditions involving the thyroid and parathyroid glands. 2 (1%) individuals were reported to have head & neck tumors. 39 (24%) individuals were reported to have congenital malformations or abnormalities of the head & neck. 47 (29%) individuals were reported to have feeding difficulties. 16% of individuals were reported to have other otolaryngologic conditions. CONCLUSIONS: Our review found multiple otolaryngologic conditions present in patients with SOTOS1, including hearing loss, otitis, hyperthyroidism, hypothyroidism, head & neck tumors, congenital malformations (high arched palate, cleft lip and palate, macroglossia), feeding difficulties, respiratory difficulties, and speech disorders. Additional studies should be conducted to further assess these associations. PMID:33640723 | DOI:10.1016/j.ijporl.2021.110649 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.