A novel clinical signature predicts the survival of elderly patients with oral squamous cell carcinoma

xlomafota13 shared this article with you from Inoreader A novel clinical signature predicts the survival of elderly patients with oral squamous cell carcinoma Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Mar 30. doi: 10.1007/s00405-021-06786-6. Online ahead of print. ABSTRACT BACKGROUND: The risk factors for the survival of elderly patients with oral squamous cell carcinoma (OSCC) are multifarious. Here, we developed a novel clinical signature to serve as an indicator of prognosis in these patients. MATERIALS AND METHODS: Clinicopathological data were collected for 554 patients aged ≥ 60 years who were treated for primary OSCC. Overall survival (OS), disease-specific survival, and disease-free survival were the primary outcomes. RESULTS: Multivariate cox regression analysis showed that high N stage, low hemoglobin level, low body mass index (BMI), and high neutrophil-to-lymphocyte ratio (NLR) showed a poor survival (P < 0.05). A nomogram was constructed with a c-index of 0.702. CONCLUSION: A novel clinical signature including hemoglobin level, BMI, and NLR, which are obtained throu gh noninvasive examinations can be used as prognostic indicators in clinical practice for elderly patients with OSCC. PMID:33783598 | DOI:10.1007/s00405-021-06786-6 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.