Reverse hybrid therapy for Helicobacter pylori eradication

xloma.fota13 shared this article with you from Inoreader Message: The standard hybrid regimen is functionally a combination of sequential therapy and concomitant therapy as it consists of a proton pump inhibitor (PPI) and amoxicillin for 10-14 d with the addition of clarithromycin and metronidazole for the final 7 d (i.e., a 2 + 4 regimen). Reverse hybrid therapy is a combination of sequential and concomitant therapy, using the same drugs as hybrid therapy, but in reverse sequence, as follows: PPI plus amoxicillin plus 2 other antibiotics (usually, clarithromycin and metronidazole) for 7 days then. PPI plus amoxicillin for 3–7 days. Reverse hybrid therapy for Helicobacter pylori eradication: A systematic review and meta‐analysis Via Helicobacter ABSTRACT Background The efficacy and safety of reverse hybrid therapy in the treatment of Helicobacter pylori (H. pylori) infection remained unclear. Materials and Methods This systematic review was performed in accordance with the PRISMA 2009 guidelines. A systematic search of the Pubmed, Embase, and Cochrane database was conducted using the combination of "Helicobacter pylori or H. pylori or Hp" and "hybrid". The primary endpoint of this meta‐analysis was to evaluate the efficacy of reverse hybrid therapy; the second endpoint was to evaluate the efficacy of reverse hybrid therapy among the strains with antibiotic resistance and the compliance, safety of reverse hybrid therapy. Results Four studies with 1530 participants were included. The crude H. pylori eradication rate of reverse hybrid therapy was 95.5% (737/772) and 96.2% (701/729) by ITT and PP analysis, respectively. There is no statistical significance of efficacy between reverse hybrid therapy and control according to ITT (pooled rate: 96% vs. 94%, RR = 1.02, 95% CI, 0.95–1.05, p = .28) and PP (pooled rate: 96% vs. 94%, RR = 1.02, 95% CI, 0.99–1.06, p = .23) analysis. The effect of reverse hybrid therapy in strains with isolated clarithromycin resistance (pooled rate: 89% vs. 65%, RR = 1.13, 95% CI, 0.77–1.66, p = .53), metronidazole resistance (pooled rate: 91% vs. 81%, RR = 1.00, 95% CI, 0.96–1.05, p = .85), and dual clarithromycin‐metronidazole resistance (pooled rate: 86% vs. 83%, RR = 0.94, 95% CI, 0.69–1.27, p = .69) showed no superio r to that of control. The compliance of reverse hybrid therapy is 96%, and side effect is slightly lower to that of control group. Conclusion Reverse hybrid therapy shows good efficacy, safety, and compliance in the treatment of H. pylori infection. However, its application for H. pylori treatment in regions with high antibiotic resistance need to be further explored. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.