Comparison of Polycaprolactone and Calcium Hydroxylapatite Dermal Fillers in A Rat Model

xloma.fota13 shared this article with you from Inoreader Comparison of Polycaprolactone and Calcium Hydroxylapatite Dermal Fillers in A Rat Model Via Dermatologic Therapy ABSTRACT Background Polycaprolactone and Calcium hydroxylapatite are semi‐permanent dermal fillers that are frequently preferred in the last decade. Objective This study aims to compare the effects of these two fillers in the rat skin. Methods 30 female rats were divided into; control, polycaprolactone, and calcium hydroxylapatite group. Tissue samples taken at the 2nd and 4th month were stained with hematoxylin‐eosin, Masson trichrome, collagen type 1, and 3 immunohistochemical antibodies. Collagen density was quantitatively compared using the Image J computer program. Results At 2 and 4 month, the density of collagen increased in both filler groups compared to the control group. There was no significant difference between collagen density or type 1 and type 3 collagen H scores in the filler groups. The number of fibroblast nuclei was significantly higher in the PCL group at 4 month compared to the other two groups. Dermis thickness was found to be superior in both filler groups compared to the control group at the 4th month, there was no significant difference between the filler groups. Conclusions We compared the effect of CaHA and PCL filler on collagenization histologically and immunohistochemically. We found that PCL and CaHA fillers are effective in increasing dermal collagen density, type 1 and type 3 collagen amount, and preventing dermis atrophy and showed that they have no advantage over each other in this respect. We have shown that PCL filler provides more fibroblast increase compared to CaHA filler and the effect of stimulating fibroblast proliferation takes longer. This article is protected by copyright. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.