Cancers, Vol. 13, Pages 53: Prognostic Clinical and Biologic Features for Overall Survival after Relapse in Childhood Medulloblastoma

xloma.fota13 shared this article with you from Inoreader Cancers, Vol. 13, Pages 53: Prognostic Clinical and Biologic Features for Overall Survival after Relapse in Childhood Medulloblastoma Via Cancers Cancers, Vol. 13, Pages 53: Prognostic Clinical and Biologic Features for Overall Survival after Relapse in Childhood Medulloblastoma Cancers doi: 10.3390/cancers13010053 Authors: Sophie Huybrechts Gwénaël Le Teuff Arnault Tauziède-Espariat Caroline Rossoni Anaïs Chivet Émilie Indersie Pascale Varlet Stéphanie Puget Rachid Abbas Olivier Ayrault Léa Guerrini-Rousseau Jacques Grill Dominique Valteau-Couanet Christelle Dufour Given the very poor prognosis for children with recurrent medulloblastoma, we aimed to identify prognostic factors for survival post-relapse in children with childhood medulloblastoma. We retrospectively collected clinico-biological data at diagnosis and main clinical characteristics at relapse of children newly diagnosed with a medulloblastoma between 2007 and 2017 at Gustave Roussy and Necker Hospital. At a median follow-up of 6.6 years (range, 0.4–12.3 years), relapse occurred in 48 out 155 patients (31%). The median time from diagnosis to relapse was 14.3 months (range, 1.2–87.2 months). Relapse was local in 9, metastatic in 22 and combined (local and metastatic) in 17 patients. Second-line treatment consisted of chemotherapy in 31 cases, radiotherapy in 9, SHH-inhibitor in four and no treatment in the remaining four. The 1-year overall survival rate post-relapse was 44.8% (CI 95%, 31.5% to 59.0%). While molecular subgrouping at diagnosis was significantly associated with survival post-relapse, the use of radiotherapy at relapse and time to first relapse (>12 months) might also have a potential impact on post-relapse survival. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.