Immunotherapy in gastroesophageal cancers: Current state and future directions.

ola Kala shared this article with you from Inoreader Immunotherapy in gastroesophageal cancers: Current state and future directions. Μέσω pubmed: "j oncol pharm pract... Immunotherapy in gastroesophageal cancers: Current state and future directions. J Oncol Pharm Pract. 2020 Oct 13;:1078155220963538 Authors: Shaikh H, Kamran A, Monga DK Abstract While gastroesophageal (GE) cancers are one of the most common cancers worldwide, unfortunately, the mortality remains high. Commonly used treatment options include surgical resection, chemotherapy, radiotherapy, and molecular targeted therapy, which improve survival only minimally; thus, affirming the dire need for exploring alternative strategies to improve patient outcomes. Immunotherapy, which has revolutionized the world of oncology, has somewhat lagged behind in GE malignancies. Tumor-associated microenvironment and regulatory T cells, alongside cell cycle checkpoints, have been proposed by various studies as the mediators of carcinogenesis in GE cancers. Thus, inhibition of each of these could serve as a possible target of treatment. While the approval of pembrolizumab has provided some hope, it is not enough to override the dismal prognosis that this disease confers. Herein, we discuss the prospects of immunotherapy in this variety of cancer. PMID: 33050805 [PubMed - as supplied by publisher] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.