Chronic Rhinosinusitis With Nasal Polyps and Asthma.

ola Kala shared this article with you from Inoreader Chronic Rhinosinusitis With Nasal Polyps and Asthma. Μέσω pubmed: treatment of nasal p... Chronic Rhinosinusitis With Nasal Polyps and Asthma. J Allergy Clin Immunol Pract. 2020 Oct 13;: Authors: Laidlaw TM, Mullol J, Woessner KM, Amin N, Mannent LP Abstract Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) characterized by a type 2 immune signature often have severe and recurrent disease. Lower airway conditions such as asthma are common comorbidities and share similar pathophysiology. CRSwNP with asthma is characterized by tissue eosinophilia and high local immunoglobulin E (IgE) levels. Clinically, CRSwNP with comorbid asthma is associated with more severe sinonasal symptoms and worse quality of life, and it is more difficult to treat both medically and surgically. Asthma in the presence of nasal polyposis is also more difficult to control, being more exacerbation prone, with increased airway obstruction and more extensive eosinophilic inflammation. Aspirin/NSAID-exacerbated respiratory disease (AERD) is a recognized phenotype of CRSwNP with comorbid asthma. CRSwNP patients with comorbid AERD are among those with the most severe and difficult-to-treat disease, and tend to have severe NP. The shared pathophysiolog y of the upper and lower airways has important implications for both the diagnosis and management of respiratory comorbidities. However, in clinical practice the nose and lungs are often treated as separate entities. The underlying systemic inflammatory link between CRSwNP and asthma provides a compelling rationale for systemic treatment with novel biologics targeting shared underlying type 2 inflammatory pathways. PMID: 33065369 [PubMed - as supplied by publisher] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.