Successful treatment of drug reaction with eosinophilia and systemic symptoms syndrome relapse with oral pulsed dexamethasone

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe hypersensitivity reaction that can be life threatening. Long-term treatment with corticosteroids is required in the management of DRESS syndrome, and relapse or worsening of symptoms after a short course of steroids after initial improvement is common. Oral steroid pulse therapy has been used to treat various dermatologic conditions with the goal of reducing toxicity associated with sustained steroid use. The use of oral pulse therapy in the treatment of DRESS syndrome has not been reported.