Purpura fulminans–like lesions in antiphospholipid syndrome with endothelial C3 deposition

Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence of antiphospholipid antibodies (aPL) associated with thrombosis or pregnancy morbidity. These antibodies include lupus anticoagulant (LA), anticardiolipin antibody (ACL), and anti–β2-glycoprotein antibody (anti-β2GPI). APS can be either primary or secondary to autoimmune diseases, mainly to systemic lupus erythematosus, but it can also be associated with other autoimmune, malignant, or drug-induced diseases.1